Cell cycle and apoptosis regulator 2 (Q21117052)

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mammalian protein found in Homo sapiens

p30 DBC
p30 DBC protein
CCAR2
DBC-1
DBC.1
DBIRD complex subunit KIAA1967
cell division cycle and apoptosis regulator protein 2
deleted in breast cancer 1
cell cycle and apoptosis regulator protein 2
Deleted in breast cancer gene 1 protein
NET35
Cell cycle and apoptosis regulator protein 2
CCAR2 protein, human

Language	Label	Description	Also known as
English	Cell cycle and apoptosis regulator 2	mammalian protein found in Homo sapiens	p30 DBC p30 DBC protein CCAR2 DBC-1 DBC.1 DBIRD complex subunit KIAA1967 cell division cycle and apoptosis regulator protein 2 deleted in breast cancer 1 cell cycle and apoptosis regulator protein 2 Deleted in breast cancer gene 1 protein NET35 Cell cycle and apoptosis regulator protein 2 CCAR2 protein, human

Statements

1 reference

13 November 2019

UniProt protein ID

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

17 September 2016

2 references

13 November 2019

UniProt protein ID

UniProt protein ID

20 March 2016

language of work or name

molecular function

RNA polymerase II complex binding

determination method or standard

1 reference

17 October 2017

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

enzyme inhibitor activity

determination method or standard

5 references

8 April 2019

Inhibition of SUV39H1 methyltransferase activity by DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Negative regulation of the deacetylase SIRT1 by DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBC1 is a negative regulator of SIRT1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

protein binding

determination method or standard

11 references

8 April 2019

Repression of estrogen receptor beta function by putative tumor suppressor DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Identification of DBC1 as a transcriptional repressor for BRCA1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBC1 is a negative regulator of SIRT1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Negative regulation of the deacetylase SIRT1 by DBC1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Global landscape of HIV-human protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

3 references

8 April 2019

Inhibition of SUV39H1 methyltransferase activity by DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBC1 is a negative regulator of SIRT1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

RNA polymerase II complex binding

determination method or standard

nuclear receptor coactivator activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Identification of DBC1 as a transcriptional repressor for BRCA1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

mitochondrial matrix

determination method or standard

1 reference

8 April 2019

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

spliceosomal complex

determination method or standard

1 reference

17 October 2017

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

7 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

Repression of estrogen receptor beta function by putative tumor suppressor DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

Identification of DBC1 as a transcriptional repressor for BRCA1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

8 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Repression of estrogen receptor beta function by putative tumor suppressor DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Identification of DBC1 as a transcriptional repressor for BRCA1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E5RHJ4

determination method or standard

biological process

mitochondrial fragmentation involved in apoptotic process

determination method or standard

1 reference

8 April 2019

Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

regulation of protein stability

determination method or standard

1 reference

8 April 2019

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

positive regulation of DNA damage checkpoint

determination method or standard

1 reference

8 April 2019

Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

rhythmic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

positive regulation of canonical Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

mRNA processing

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

regulation of DNA-templated transcription, elongation

determination method or standard

1 reference

8 April 2019

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

regulation of protein deacetylation

determination method or standard

1 reference

8 April 2019

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

determination method or standard

1 reference

8 April 2019

Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

Wnt signaling pathway

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

negative regulation of cell growth

determination method or standard

1 reference

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

3 references

17 October 2017

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8N163&geneProductId=UniProtKB:Q8N163

determination method or standard

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

determination method or standard

1 reference

8 April 2019

DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erbα

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

positive regulation of apoptotic process

determination method or standard

3 references

8 April 2019

Negative regulation of the deacetylase SIRT1 by DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

DBC1 is a negative regulator of SIRT1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

regulation of cellular response to heat

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

3 references

8 April 2019

Repression of estrogen receptor beta function by putative tumor suppressor DBC1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

CCAR2 negatively regulates nuclear receptor LXRα by competing with SIRT1 deacetylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Identification of DBC1 as a transcriptional repressor for BRCA1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

1 reference

8 April 2019

Deleted in breast cancer 1 (DBC1) deficiency results in apoptosis of breast cancer cells through impaired responses to UV-induced DNA damage

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

apoptotic process

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

4 references

8 April 2019

DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

positive regulation of nucleic acid-templated transcription

determination method or standard

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8N163

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E5RHJ4

determination method or standard

positive regulation of apoptotic process

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:E5RHJ4

determination method or standard

DBC1/CARP1 catalytically inactive NUDIX hydrolase domain

2 references

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N163

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/E5RHJ4

S1-like RNA binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8N163

Identifiers

MeSH descriptor ID

subject named as

CCAR2 protein, human

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

UniProt protein ID

20 March 2016

language of work or name

Ensembl protein ID

ENSP00000310670

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000310670

ENSP00000373930

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000373930

ENSP00000428549

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428549

ENSP00000428843

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000428843

ENSP00000429739

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429739

ENSP00000429769

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429769

ENSP00000429773

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000429773

ENSP00000430974

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430974

ENSP00000430978

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000430978

ENSP00000431046

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431046

ENSP00000484850

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000484850

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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