Mitochondrial calcium uniporter (Q21120000)

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mammalian protein found in Homo sapiens
  • calcium uniporter protein, mitochondrial
  • MCU
  • coiled-coil domain-containing protein 109A
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Language Label Description Also known as
English
Mitochondrial calcium uniporter
mammalian protein found in Homo sapiens
  • calcium uniporter protein, mitochondrial
  • MCU
  • coiled-coil domain-containing protein 109A

Statements

molecular function
protein binding
determination method
IPI
7 references
retrieved
8 April 2019
stated in
MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
retrieved
8 April 2019
stated in
SLC25A23 augments mitochondrial Ca²⁺ uptake, interacts with MCU, and induces oxidative stress-mediated cell death
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IPI
uniporter activity
determination method
IBA
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
MCU encodes the pore conducting mitochondrial calcium currents
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IEA
retrieved
8 April 2019
stated in
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IDA
retrieved
8 April 2019
stated in
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IDA
retrieved
8 April 2019
stated in
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IBA
cell component
biological process
mitochondrial calcium ion transmembrane transport
determination method
IDA
IEA
IMP
TAS
6 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
TAS
retrieved
8 April 2019
stated in
MCU encodes the pore conducting mitochondrial calcium currents
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IMP
retrieved
8 April 2019
stated in
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IEA
retrieved
8 April 2019
stated in
MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IDA
retrieved
8 April 2019
stated in
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
GOA
curator
UniProt
UniProt protein ID
Q8NE86
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8NE86
determination method
IDA

Identifiers

 
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