MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity (Q24338031)

Mitochondrial calcium uniporter

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Mitochondrial calcium uptake 2

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Mitochondrial calcium uptake 1

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Mitochondrial calcium uptake 2

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author

Anna Raffaello

3

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7 June 2020

Denis Vecellio Reane

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7 June 2020

Ildikó Szabó

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7 June 2020

Diego De Stefani

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7 June 2020

Rosario Rizzuto

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Enrico Teardo

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7 June 2020

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Vanessa Checchetto

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7 June 2020

author name string

Maria Patron

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Maura Mantoan

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Veronica Granatiero

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language of work or name

English

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publication date

6 March 2014

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published in

Molecular Cell

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volume

53

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issue

5

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page(s)

726-737

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describes a project that uses

7 June 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3988891/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

EMRE is an essential component of the mitochondrial calcium uniporter complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

Fiji: an open-source platform for biological-image analysis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

Ultrasensitive fluorescent proteins for imaging neuronal activity

19 March 2017

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Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

7 April 2017

1 reference

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Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy

7 April 2017

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Mitochondria as sensors and regulators of calcium signalling

27 September 2017

1 reference

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Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels.

27 September 2017

1 reference

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Regulation of mitochondrial dehydrogenases by calcium ions

27 September 2017

1 reference

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Biosensors for the detection of calcium and pH.

27 September 2017

1 reference

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Biophysics and structure-function relationship of T-type Ca2+ channels

27 September 2017

1 reference

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Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming

27 September 2017

1 reference

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Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria

27 September 2017

1 reference

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Role of calcium ions in regulation of mammalian intramitochondrial metabolism

27 September 2017

1 reference

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MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3988891

CHELATOR: an improved method for computing metal ion concentrations in physiological solutions.

30 May 2018

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Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling

30 May 2018

1 reference

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The mitochondrial calcium uniporter is a highly selective ion channel.

29 November 2018

1 reference

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10.1016/J.MOLCEL.2014.01.013

29 November 2018

Identifiers

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