Leucine rich repeat containing G protein-coupled receptor 5 (Q21121563)

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mammalian protein found in Homo sapiens

G-protein coupled receptor 49
G-protein coupled receptor 67
orphan G protein-coupled receptor HG38
LGR5
G-protein coupled receptor HG38
leucine-rich repeat-containing G-protein coupled receptor 5

Language	Label	Description	Also known as
English	Leucine rich repeat containing G protein-coupled receptor 5	mammalian protein found in Homo sapiens	G-protein coupled receptor 49 G-protein coupled receptor 67 orphan G protein-coupled receptor HG38 LGR5 G-protein coupled receptor HG38 leucine-rich repeat-containing G-protein coupled receptor 5

Statements

1 reference

13 November 2019

UniProt protein ID

Leucine-rich repeat domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75473

Glycoprotein hormone receptor family

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75473

Leucine-rich repeat N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, typical subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Leucine-rich repeat, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

4 references

8 April 2019

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

G protein-coupled receptor activity

determination method

3 references

8 April 2019

Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

transmembrane signaling receptor activity

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

signal transducer activity

determination method

1 reference

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75473&geneProductId=UniProtKB:O75473

determination method

protein-hormone receptor activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

G protein-coupled peptide receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

plasma membrane

determination method

2 references

Golgi apparatus

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

integral component of plasma membrane

determination method

4 references

16 July 2018

Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75473&geneProductId=UniProtKB:O75473

determination method

16 July 2018

Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75473&geneProductId=UniProtKB:O75473

determination method

16 July 2018

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75473&geneProductId=UniProtKB:O75473

determination method

16 July 2018

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75473&geneProductId=UniProtKB:O75473

determination method

trans-Golgi network membrane

determination method

1 reference

8 April 2019

Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

integral component of plasma membrane

determination method

5 references

8 April 2019

Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

biological process

positive regulation of canonical Wnt signaling pathway

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

8 April 2019

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

hair follicle development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

inner ear development

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

G protein-coupled receptor signaling pathway

determination method

3 references

epithelial cell proliferation involved in renal tubule morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

regulation of cell population proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

oocyte differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

activation of adenylate cyclase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

hormone-mediated signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75473

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000266674

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000266674

ENSP00000441035

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441035

ENSP00000443033

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443033

PDB structure ID

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

1 reference

UniProt protein ID

21 March 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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