R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 (Q21560784)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

title

R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

Leucine rich repeat containing G protein-coupled receptor 4

8 February 2020

main subject

1 reference

R-spondin 1

1 reference

Leucine rich repeat containing G protein-coupled receptor 5

1 reference

G protein-coupled receptor activity

1 reference

17

Ieuan Clay

Ieuan

Clay

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

27

Fred Bassilana

Fred

Bassilana

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Heinz Ruffner

1

Heinz

Ruffner

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Joëlle Sprunger

2

Joëlle

Sprunger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Olga Charlat

3

Olga

Charlat

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Juliet Leighton-Davies

4

Juliet

Leighton-Davies

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Bianka Grosshans

5

Bianka

Grosshans

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Adrian Salathe

6

Adrian

Salathe

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Svenja Zietzling

7

Svenja

Zietzling

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Valérie Beck

8

Valérie

Beck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Maxime Therier

9

Maxime

Therier

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Andrea Isken

10

Andrea

Isken

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Yang Xie

11

Yang

Xie

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Yue Zhang

12

Yue

Zhang

1 reference

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8 February 2020

Huaixiang Hao

13

Huaixiang

Hao

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Xiaoying Shi

14

Xiaoying

Shi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Dong Liu

15

Dong

Liu

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Qinhui Song

16

Qinhui

Song

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Gabriele Hintzen

18

Gabriele

Hintzen

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jan Tchorz

19

Jan

Tchorz

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Laure C Bouchez

20

Laure C

Bouchez

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Gregory Michaud

21

Gregory

Michaud

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Peter Finan

22

Peter

Finan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Vic E Myer

23

Vic E

Myer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Tewis Bouwmeester

24

Tewis

Bouwmeester

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Jeff Porter

25

Jeff

Porter

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Marc Hild

26

Marc

Hild

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Christian N Parker

28

Christian N

Parker

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

Feng Cong

29

Feng

Cong

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

language of work or name

English

0 references

publication date

16 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

volume

7

1 reference

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8 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

page(s)

e40976

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

8 February 2020

copyright license

start time

16 July 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

1 reference

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R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling

19 March 2017

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

19 March 2017

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R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6

19 March 2017

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Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

19 March 2017

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19 March 2017

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Identification of stem cells in small intestine and colon by marker gene Lgr5

19 March 2017

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Regulation of bone formation and remodeling by G-protein-coupled receptor 48

19 March 2017

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

19 March 2017

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Defective postnatal development of the male reproductive tract in LGR4 knockout mice

19 March 2017

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The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7

19 March 2017

1 reference

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Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region

19 March 2017

1 reference

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Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3

19 March 2017

1 reference

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R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants

19 March 2017

1 reference

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Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density

19 March 2017

1 reference

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

24 March 2017

1 reference

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Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro

7 April 2017

1 reference

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LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.

7 April 2017

1 reference

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Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

12 September 2017

1 reference

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R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway

12 September 2017

1 reference

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Inactivation of G-protein-coupled receptor 48 (Gpr48/Lgr4) impairs definitive erythropoiesis at midgestation through down-regulation of the ATF4 signaling pathway

12 September 2017

1 reference

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Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2.

12 September 2017

1 reference

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R-Spondin family members regulate the Wnt pathway by a common mechanism

12 September 2017

1 reference

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

12 September 2017

1 reference

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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

12 September 2017

1 reference

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Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo

12 September 2017

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Paneth cell differentiation in the developing intestine of normal and transgenic mice

12 September 2017

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Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.

12 September 2017

1 reference

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12 September 2017

Adenylate cyclase assay

1 reference

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Generation of a constitutively active mutant of human GPR48/LGR4, a G-protein-coupled receptor.

12 September 2017

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Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo

27 September 2017

1 reference

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Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397969

Defective development of the gall bladder and cystic duct in Lgr4- hypomorphic mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397969

Impaired hair placode formation with reduced expression of hair follicle-related genes in mice lacking Lgr4.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397969

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397969

Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3397969

Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22815884

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Leucine-rich repeat-containing G protein-coupled receptor-4 (LGR4, Gpr48) is essential for renal development in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22815884

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0040976

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json

8 February 2020

PubMed publication ID

22815884

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22815884%20AND%20SRC:MED&resulttype=core&format=json