P21 (RAC1) activated kinase 2 (Q21130016)

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mammalian protein found in Homo sapiens
  • PAK-2
  • PAK65
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • serine/threonine-protein kinase PAK 2
  • p58
  • p21 (CDKN1A)-activated kinase 2
  • S6/H4 kinase
  • p21-activated kinase 2
  • gamma-PAK
  • PAK2
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Language Label Description Also known as
English
P21 (RAC1) activated kinase 2
mammalian protein found in Homo sapiens
  • PAK-2
  • PAK65
  • p21 protein (Cdc42/Rac)-activated kinase 2
  • serine/threonine-protein kinase PAK 2
  • p58
  • p21 (CDKN1A)-activated kinase 2
  • S6/H4 kinase
  • p21-activated kinase 2
  • gamma-PAK
  • PAK2

Statements

molecular function
protein serine/threonine kinase activity
determination method
EXP
IDA
TAS
IEA
8 references
retrieved
27 February 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
TAS
retrieved
27 February 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q13177
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
IEA
retrieved
27 February 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
IEA
retrieved
27 February 2018
stated in
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
IDA
retrieved
27 February 2018
stated in
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
IDA
retrieved
27 February 2018
stated in
Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
EXP
retrieved
27 February 2018
stated in
VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
EXP
retrieved
27 February 2018
stated in
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q13177&geneProductId=UniProtKB:Q13177
determination method
EXP
protein binding
determination method
IPI
15 references
retrieved
8 April 2019
stated in
Identification of the Nef-associated kinase as p21-activated kinase 2
GOA
curator
UniProt
UniProt protein ID
Q13177
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Scrib regulates PAK activity during the cell migration process
GOA
curator
UniProt
UniProt protein ID
Q13177
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
betaPIX controls cell motility and neurite extension by regulating the distribution of GIT1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Huntingtin promotes cell survival by preventing Pak2 cleavage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
A human MAP kinase interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
WNT-3a modulates platelet function by regulating small GTPase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Alphaherpesvirus US3-mediated reorganization of the actin cytoskeleton is mediated by group A p21-activated kinases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
PLC-gamma1 and Rac1 coregulate EGF-induced cytoskeleton remodeling and cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
retrieved
8 April 2019
stated in
POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IPI
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
TAS
7 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
TAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q13177
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IEA
retrieved
8 April 2019
stated in
Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST)
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IDA
retrieved
8 April 2019
stated in
Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
IBA
retrieved
8 April 2019
stated in
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13177
determination method
EXP
cell component
biological process

Identifiers

Freebase ID
/m/02kgp63
0 references
 
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