The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity (Q28118693)

P21 (RAC1) activated kinase 1

GOA release 2020-03-11

1 reference

protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

C. Chong

1

1 reference

4 January 2017

L. Tan

2

1 reference

4 January 2017

L. Lim

3

1 reference

4 January 2017

E. Manser

Journal of Biological Chemistry

4

1 reference

4 January 2017

language of work or name

English

0 references

publication date

18 May 2001

1 reference

4 January 2017

1 reference

4 January 2017

276

1 reference

4 January 2017

20

1 reference

4 January 2017

17347–17353

1 reference

4 January 2017

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Inhibition of myosin light chain kinase by p21-activated kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Molecular cloning and sequencing of the cytostatic G protein-activated protein kinase PAK I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Structure of Cdc42 bound to the GTPase binding domain of PAK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Determinants for substrate phosphorylation by p21-activated protein kinase (gamma-PAK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

A novel regulator of p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

p21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Integrin-mediated signals regulated by members of the rho family of GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

A role for p21-activated kinase in endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M009316200

21 January 2018

Identifiers

DOI

10.1074/JBC.M009316200

1 reference

Consolidated OpenCitations Corpus – April 2017

release_y2yzj6tobrck7cw5sleysniknu

3219306

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/y2yzj6tobrck7cw5sleysniknu

mapped directly with Wikidata item

24 November 2022

based on heuristic

3219306

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference