Eukaryotic translation initiation factor 4E binding protein 1 (Q21130676)

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mammalian protein found in Homo sapiens
  • eIF4E-binding protein 1
  • PHAS-I
  • eukaryotic translation initiation factor 4E-binding protein 1
  • EIF4EBP1
  • phosphorylated heat- and acid-stable protein regulated by insulin 1
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Language Label Description Also known as
English
Eukaryotic translation initiation factor 4E binding protein 1
mammalian protein found in Homo sapiens
  • eIF4E-binding protein 1
  • PHAS-I
  • eukaryotic translation initiation factor 4E-binding protein 1
  • EIF4EBP1
  • phosphorylated heat- and acid-stable protein regulated by insulin 1

Statements

molecular function
protein binding
determination method
IPI
19 references
retrieved
8 April 2019
stated in
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
GOA
curator
UniProt
UniProt protein ID
Q13541
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods
GOA
curator
UniProt
UniProt protein ID
Q13541
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms
GOA
curator
UniProt
UniProt protein ID
Q13541
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Eukaryotic translation initiation is controlled by cooperativity effects within ternary complexes of 4E-BP1, eIF4E, and the mRNA 5' cap
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
An oxygen-regulated switch in the protein synthesis machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Towards a proteome-scale map of the human protein–protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Local control of a disorder-order transition in 4E-BP1 underpins regulation of translation via eIF4E.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Sumoylation of eIF4E activates mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of human eIF4E by 4E-BP1: binding analysis using surface plasmon resonance
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Characterization of mammalian eIF4E-family members
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
retrieved
8 April 2019
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q13541
determination method
IPI
cell component
biological process

Identifiers

PDB structure ID
 
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                    Retrieved from "https://www.wikidata.org/w/index.php?title=Q21130676&oldid=2023013518"