Phospholipid scramblase 1 (Q21130721)

http://www.ebi.ac.uk/interpro/protein/O15162

Transporter Classification Database ID

9.A.36.1.1

retrieved

2 October 2019

based on heuristic

hierarchical database ID heuristic

1 reference

13 November 2019

1 reference

13 November 2019

phospholipid scramblase activity

3 references

26 September 2017

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

epidermal growth factor receptor binding

IPI

1 reference

9 May 2019

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

DNA-binding transcription activator activity, RNA polymerase II-specific

IPI

2 references

10 references

9 May 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Identification of PLSCR1 as a protein that interacts with RELT family members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Widespread macromolecular interaction perturbations in human genetic disorders

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phospholipid scramblase 1 mediates hepatitis C virus entry into host cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Protein interactions of the transcription factor Hoxa1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

3 references

9 May 2019

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

phospholipid scramblase activity

IPI

4 references

8 April 2019

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

phospholipid scramblase activity

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

integral component of membrane

cell component

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

26 September 2017

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

5 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

integral component of plasma membrane

2 references

9 May 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

3 references

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Identification of PLSCR1 as a protein that interacts with RELT family members

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

collagen-containing extracellular matrix

1 reference

9 May 2019

Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

phosphatidylserine biosynthetic process

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

regulation of mast cell activation

ISS

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

plasma membrane phospholipid scrambling

ISS

3 references

26 September 2017

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

26 September 2017

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity

1 reference

9 May 2019

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

response to interferon-beta

1 reference

9 May 2019

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

regulation of Fc receptor mediated stimulatory signaling pathway

IMP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

negative regulation of viral genome replication

NAS

1 reference

9 May 2019

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

positive regulation of gene expression

IMP

1 reference

9 May 2019

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

positive regulation of innate immune response

ISS

1 reference

9 May 2019

Phospholipid scramblase 1 potentiates the antiviral activity of interferon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

positive regulation of transcription by RNA polymerase II

IMP

1 reference

9 May 2019

Phospholipid scramblase 1 binds to the promoter region of the inositol 1,4,5-triphosphate receptor type 1 gene to enhance its expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

1 reference

9 May 2019

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

transcription by RNA polymerase II

1 reference

26 September 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15162&geneProductId=UniProtKB:O15162

plasma membrane phospholipid scrambling

IEA

4 references

8 April 2019

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

plasma membrane phospholipid scrambling

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Molecular cloning of human plasma membrane phospholipid scramblase. A protein mediating transbilayer movement of plasma membrane phospholipids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Over-expression of recombinant human phospholipid scramblase 1 in E. coli and its purification from inclusion bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15162