Small nuclear ribonucleoprotein D2 polypeptide (Q21132583)

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mammalian protein found in Homo sapiens

small nuclear ribonucleoprotein Sm D2
SNRPD2
snRNP core protein D2
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

Language	Label	Description	Also known as
English	Small nuclear ribonucleoprotein D2 polypeptide	mammalian protein found in Homo sapiens	small nuclear ribonucleoprotein Sm D2 SNRPD2 snRNP core protein D2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

Statements

1 reference

13 November 2019

UniProt protein ID

Small nuclear ribonucleoprotein Sm D2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62316

LSM domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62316

LSM domain, eukaryotic/archaea-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

10 references

8 April 2019

Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

A protein interaction framework for human mRNA degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Multiple protein: protein interactions between the snRNP common core proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

U1 snRNP binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

SMN-Sm protein complex

determination method

1 reference

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

catalytic step 2 spliceosome

determination method

1 reference

26 September 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

U4/U6 x U5 tri-snRNP complex

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

U12-type spliceosomal complex

determination method

1 reference

8 April 2019

The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

precatalytic spliceosome

determination method

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

pICln-Sm protein complex

determination method

1 reference

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

8 April 2019

Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

extracellular exosome

determination method

determination method

1 reference

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

determination method

1 reference

26 September 2017

Functional organization of the Sm core in the crystal structure of human U1 snRNP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P62316&geneProductId=UniProtKB:P62316

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

3 references

1 January 2018

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

1 January 2018

Functional organization of the Sm core in the crystal structure of human U1 snRNP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

extracellular exosome

determination method

1 reference

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

U2-type precatalytic spliceosome

determination method

1 reference

8 April 2019

Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

U2-type catalytic step 2 spliceosome

determination method

1 reference

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Functional organization of the Sm core in the crystal structure of human U1 snRNP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

biological process

mRNA processing

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

spliceosomal complex assembly

determination method

1 reference

8 April 2019

cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

determination method

3 references

8 April 2019

Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

import into nucleus

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

spliceosomal snRNP assembly

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

mRNA splicing, via spliceosome

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

8 April 2019

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P62316

determination method

LSM domain, eukaryotic/archaea-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P62316

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000342374

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000342374

ENSP00000375798

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000375798

ENSP00000465216

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465216

ENSP00000465952

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465952

ENSP00000466152

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466152

ENSP00000465101

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465101

ENSP00000468247

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468247

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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