Nectin cell adhesion molecule 2 (Q21132881)

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mammalian protein found in Homo sapiens

HveB
poliovirus receptor-related 2 (herpesvirus entry mediator B)
nectin-2
poliovirus receptor-like 2
NECTIN2
Herpesvirus entry mediator B
Herpes virus entry mediator B
herpesvirus entry protein B
Poliovirus receptor-related protein 2

Language	Label	Description	Also known as
English	Nectin cell adhesion molecule 2	mammalian protein found in Homo sapiens	HveB poliovirus receptor-related 2 (herpesvirus entry mediator B) nectin-2 poliovirus receptor-like 2 NECTIN2 Herpesvirus entry mediator B Herpes virus entry mediator B herpesvirus entry protein B Poliovirus receptor-related protein 2

Statements

1 reference

13 November 2019

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92692

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92692

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q92692

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

CD80-like, immunoglobulin C2-set, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

coreceptor activity

determination method

1 reference

8 April 2019

A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

virus receptor activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

protein binding

determination method

11 references

8 April 2019

Identification of CD112R as a novel checkpoint for human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Structural, mutational and biophysical studies reveal a canonical mode of molecular recognition between immune receptor TIGIT and nectin-2.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Nectin ectodomain structures reveal a canonical adhesive interface

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Drebrin preserves endothelial integrity by stabilizing nectin at adherens junctions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

identical protein binding

determination method

5 references

8 April 2019

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT).

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Nectin ectodomain structures reveal a canonical adhesive interface

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

A secreted protein microarray platform for extracellular protein interaction discovery

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

signaling receptor binding

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

cell adhesion molecule binding

determination method

4 references

8 April 2019

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

protein heterodimerization activity

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

protein homodimerization activity

determination method

4 references

17 October 2017

The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cell-cell junction

determination method

3 references

determination method

1 reference

17 October 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

integral component of plasma membrane

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

extracellular exosome

determination method

apical junction complex

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cell-cell contact zone

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

determination method

1 reference

8 April 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

extracellular exosome

determination method

1 reference

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

biological process

heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

sperm mitochondrion organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cell recognition

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

positive regulation of immunoglobulin mediated immune response

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

regulation of viral entry into host cell

determination method

1 reference

8 April 2019

Structural features of nectin-2 (HveB) required for herpes simplex virus entry

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

susceptibility to natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

positive regulation of mast cell activation

determination method

1 reference

8 April 2019

Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

acrosome assembly

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cytoskeleton organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

determination method

1 reference

8 April 2019

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cilium organization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

establishment of mitochondrion localization

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

regulation of immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

spermatid nucleus differentiation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

susceptibility to T cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

cell part morphogenesis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

adherens junction organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

positive regulation of natural killer cell mediated cytotoxicity

determination method

1 reference

8 April 2019

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

viral entry into host cell

determination method

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

signal transduction

determination method

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q92692&geneProductId=UniProtKB:Q92692

determination method

positive regulation of T cell receptor signaling pathway

determination method

1 reference

8 April 2019

Identification of CD112R as a novel checkpoint for human T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

virion attachment to host cell

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92692

determination method

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000252483

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252483

ENSP00000252485

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252485

ENSP00000465511

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465511

ENSP00000465587

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000465587

ENSP00000468305

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468305

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

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Multilingual sites(0 entries)

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