The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex (Q21136376)

PubMed

PubMed publication ID

20485546

Creative Commons Attribution 4.0 International

17 August 2022

language of work or name

English

0 references

publication date

2010

0 references

published in

PLOS One

0 references

volume

5

0 references

issue

5

0 references

page(s)

e10615

0 references

copyright license

start time

12 May 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors

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p53 represses c-Myc through induction of the tumor suppressor miR-145

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Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression

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Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA

19 March 2017

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A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

19 March 2017

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A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment

19 March 2017

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Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

19 March 2017

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A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells

19 March 2017

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Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure

19 March 2017

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Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA

19 March 2017

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CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease

19 March 2017

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The role of PACT in the RNA silencing pathway

19 March 2017

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The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor

19 March 2017

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TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

19 March 2017

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Biogenesis of small RNAs in animals

19 March 2017

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Switching from repression to activation: microRNAs can up-regulate translation

19 March 2017

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The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2

19 March 2017

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The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway

19 March 2017

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let-7 regulates Dicer expression and constitutes a negative feedback loop

19 March 2017

1 reference

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Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin

19 March 2017

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P68 RNA helicase unwinds the human let-7 microRNA precursor duplex and is required for let-7-directed silencing of gene expression

19 March 2017

1 reference

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The let-7 microRNA represses cell proliferation pathways in human cells

19 March 2017

1 reference

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p63 Is essential for the proliferative potential of stem cells in stratified epithelia

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

PACT is a negative regulator of p53 and essential for cell growth and embryonic development

19 March 2017

1 reference

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Relief of microRNA-mediated translational repression in human cells subjected to stress

19 March 2017

1 reference

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Dicer function is essential for lung epithelium morphogenesis

19 March 2017

1 reference

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p63 is the molecular switch for initiation of an epithelial stratification program

19 March 2017

1 reference

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The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis

19 March 2017

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p63 protects the female germ line during meiotic arrest

19 March 2017

1 reference

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The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles

19 March 2017

1 reference

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SMAD proteins control DROSHA-mediated microRNA maturation

19 March 2017

1 reference

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

DICER1 mutations in familial pleuropulmonary blastoma

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Distinct populations of tumor-initiating cells derived from a tumor generated by rat mammary cancer stem cells.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

A gene signature-based approach identifies mTOR as a regulator of p73.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Decreased Dicer expression elicits DNA damage and up-regulation of MICA and MICB.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

A requirement for DICER to maintain full promoter CpG island hypermethylation in human cancer cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

A skin microRNA promotes differentiation by repressing 'stemness'.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Dissecting microregulation of a master regulatory network

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Dicing with viruses: microRNAs as antiviral factors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Critical roles for Dicer in the female germline

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

p63 induces key target genes required for epidermal morphogenesis

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

MicroRNA biogenesis and cancer

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Maturation of microRNA is hormonally regulated by a nuclear receptor

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Stable expression of miR-200c alone is sufficient to regulate TCF8 (ZEB1) and restore E-cadherin expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

MicroRNA-125b is a novel negative regulator of p53.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Overexpression of Dicer in precursor lesions of lung adenocarcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

Relationships between p63 binding, DNA sequence, transcription activity, and biological function in human cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

CRD-BP protects the coding region of betaTrCP1 mRNA from miR-183-mediated degradation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms.

30 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

Reduced expression of Dicer associated with poor prognosis in lung cancer patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

deltaEF1 repressor controls selectively p53 family members during differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0010615

Dicer1 expression in preimplantation mouse embryos: Involvement of Oct3/4 transcription at the blastocyst stage.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2868896

The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20485546

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Differential regulation of p63 and p73 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20485546

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0010615

1 reference

ADS bibcode

2010PLoSO...510615B

0 references

1 reference

1 reference

PubMed publication ID

20485546

1 reference