Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease (Q21136406)

2

Natalia

Podlutskaya

1 reference

17 August 2022

Matthew J Hart

3

Matthew J

Hart

1 reference

17 August 2022

Olivia Gorostiza

5

Olivia

Gorostiza

1 reference

17 August 2022

Dale Bredesen

6

Dale

Bredesen

1 reference

17 August 2022

Randy Strong

8

Randy

Strong

1 reference

17 August 2022

Veronica Galvan

9

Veronica

Creative Commons Attribution 4.0 International

Galvan

1 reference

17 August 2022

language of work or name

English

0 references

publication date

2010

0 references

published in

PLOS One

0 references

volume

5

0 references

issue

4

0 references

page(s)

e9979

0 references

copyright license

start time

1 April 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

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The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span

19 March 2017

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

19 March 2017

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

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p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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Alzheimer's disease is a synaptic failure

7 April 2017

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The role of the Atg1/ULK1 complex in autophagy regulation

7 April 2017

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

7 April 2017

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FoxO3 controls autophagy in skeletal muscle in vivo

7 April 2017

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Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model

7 April 2017

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Growing roles for the mTOR pathway

7 April 2017

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Genetics: influence of TOR kinase on lifespan in C. elegans

7 April 2017

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High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

7 April 2017

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Developments of a water-maze procedure for studying spatial learning in the rat

7 April 2017

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Potential therapeutic applications of autophagy

7 April 2017

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

7 April 2017

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APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks

12 September 2017

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The regulation of aging: does autophagy underlie longevity?

12 September 2017

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12 September 2017

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Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice

12 September 2017

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Autophagy, amyloidogenesis and Alzheimer disease

12 September 2017

1 reference

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.

12 September 2017

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Protective roles for induction of autophagy in multiple proteinopathies

12 September 2017

1 reference

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Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Lithium induces clearance of protease resistant prion protein in prion-infected cells by induction of autophagy

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Autophagy induction by trehalose counteracts cellular prion infection

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Reversal of learning deficits in hAPP transgenic mice carrying a mutation at Asp664: a role for early experience

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Long-term prevention of Alzheimer's disease-like behavioral deficits in PDAPP mice carrying a mutation in Asp664.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

In search of an "autophagomometer".

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Monitoring autophagic degradation of p62/SQSTM1.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

On the participation of mTOR in recognition memory

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2848616

10.1371/JOURNAL.PONE.0009979

29 November 2018

Identifiers

DOI

1 reference

release_u2tqmh5tcfgrjbrdco6efp53k4

0 references

0 references

93636

1 reference

1 reference

1 reference