Wolframin ER transmembrane glycoprotein (Q21136669)

http://www.ebi.ac.uk/interpro/protein/O76024

Tetratricopeptide-like helical domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O76024

auxiliary protein involved in transmembrane transport

1 reference

Transporter Classification Database ID

8.A.57.1.1

hierarchical database ID heuristic

2 October 2019

based on heuristic

1 reference

13 November 2019

1 reference

13 November 2019

IPI

1 reference

9 May 2019

Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

calcium-dependent protein binding

IPI

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

calmodulin binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

proteasome binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

1 reference

9 May 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

3 references

9 May 2019

9 May 2019

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

1 reference

9 May 2019

integral component of endoplasmic reticulum membrane

2 references

9 May 2019

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Wolframin expression induces novel ion channel activity in endoplasmic reticulum membranes and increases intracellular calcium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

dendrite

ISS

1 reference

9 May 2019

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

ISS

endoplasmic reticulum

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

proteasome complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

endoplasmic reticulum lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

1 reference

9 May 2019

integral component of synaptic vesicle membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

negative regulation of neuron apoptotic process

biological process

2 references

9 May 2019

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

glucose homeostasis

1 reference

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

kidney development

1 reference

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

protein stabilization

Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

nervous system process

1 reference

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

hearing

1 reference

9 May 2019

Mutations in the WFS1 gene are a frequent cause of autosomal dominant nonsyndromic low-frequency hearing loss in Japanese

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

endoplasmic reticulum calcium ion homeostasis

1 reference

9 May 2019

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

protein maturation by protein folding

IC

1 reference

9 May 2019

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

IC

ER overload response

IC

IRE1-mediated unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

1 reference

9 May 2019

ubiquitin-dependent ERAD pathway

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

renal water homeostasis

1 reference

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

negative regulation of programmed cell death

1 reference

9 May 2019

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

positive regulation of protein ubiquitination

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

visual perception

2 references

9 May 2019

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

9 May 2019

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

positive regulation of calcium ion transport

1 reference

9 May 2019

WFS1 protein modulates the free Ca(2+) concentration in the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

pancreas development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

endoplasmic reticulum unfolded protein response

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

olfactory behavior

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

post-translational protein modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O76024

1 reference

9 May 2019

Transporter Classification Database ID

Identifiers

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

22 November 2019

1 reference

13 November 2019

1 reference

1 reference

1 reference

8.A.57.1.1

2 references

Transporter Classification database

13 March 2020

Transporter Classification database