Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells (Q24299603)

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902236

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902237

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:1902235

Wolframin ER transmembrane glycoprotein

1 reference

negative regulation of ATF6-mediated unfolded protein response

1 reference

Wolframin ER transmembrane glycoprotein

1 reference

Synovial apoptosis inhibitor 1, synoviolin

1 reference

1 reference

1 reference

Sonya G Fonseca

1

0 references

Shinsuke Ishigaki

2

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Christine M Oslowski

3

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Simin Lu

4

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Kathryn L Lipson

5

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Rajarshi Ghosh

6

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Emiko Hayashi

7

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Hisamitsu Ishihara

8

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Yoshitomo Oka

9

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M Alan Permutt

10

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Fumihiko Urano

Journal of Clinical Investigation

11

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language of work or name

English

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publication date

March 2010

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published in

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volume

120

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issue

3

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page(s)

744-55

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describes a project that uses

ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2827948/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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1 reference

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WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

19 March 2017

1 reference

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

19 March 2017

1 reference

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Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

19 March 2017

1 reference

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Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

19 March 2017

1 reference

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A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

19 March 2017

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Signal integration in the endoplasmic reticulum unfolded protein response

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19 March 2017

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A molecular chaperone inducer protects neurons from ER stress

19 March 2017

1 reference

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WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

19 March 2017

1 reference

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Missense variations of the gene responsible for Wolfram syndrome (WFS1/wolframin) in Japanese: possible contribution of the Arg456His mutation to type 1 diabetes as a nonautoimmune genetic basis

19 March 2017

1 reference

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Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis

19 March 2017

1 reference

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ER stress regulation of ATF6 localization by dissociation of BiP/GRP78 binding and unmasking of Golgi localization signals

19 March 2017

1 reference

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ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

19 March 2017

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

19 March 2017

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Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

7 April 2017

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IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

27 September 2017

1 reference

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Clinical risk factors, DNA variants, and the development of type 2 diabetes

27 September 2017

1 reference

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Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds

27 September 2017

1 reference

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Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations

27 September 2017

1 reference

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A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes

27 September 2017

1 reference

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Endoplasmic reticulum stress signaling in pancreatic beta-cells

27 September 2017

1 reference

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Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians

27 September 2017

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Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

27 September 2017

1 reference

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XBP1 induces WFS1 through an endoplasmic reticulum stress response element-like motif in SH-SY5Y cells

27 September 2017

1 reference

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WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

27 September 2017

1 reference

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Wolframin mutations and hospitalization for psychiatric illness

27 September 2017

1 reference

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Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response

27 September 2017

1 reference

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Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.

27 September 2017

1 reference

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Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

27 September 2017

1 reference

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Psychiatric findings in Wolfram syndrome homozygotes

27 September 2017

1 reference

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ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress

27 September 2017

1 reference

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Common variants in WFS1 confer risk of type 2 diabetes

30 May 2018

1 reference

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Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6.

30 May 2018

1 reference

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The role of multiubiquitination in dislocation and degradation of the alpha subunit of the T cell antigen receptor

30 May 2018

1 reference

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Mice conditionally lacking the Wolfram gene in pancreatic islet beta cells exhibit diabetes as a result of enhanced endoplasmic reticulum stress and apoptosis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827948

Disruption of the WFS1 gene in mice causes progressive beta-cell loss and impaired stimulus-secretion coupling in insulin secretion

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827948

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827948

Predisposition of Wolfram syndrome heterozygotes to psychiatric illness.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827948

Cytosolic degradation of T-cell receptor alpha chains by the proteasome

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2827948

A novel mutation of WFS1 gene in a Japanese man of Wolfram syndrome with positive diabetes-related antibodies

29 November 2018

1 reference

12 December 2020

Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6

1 reference

12 December 2020

Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6alpha and XBP1

1 reference

12 December 2020

That which does not kill me makes me stronger: adapting to chronic ER stress

1 reference

12 December 2020

A time-dependent phase shift in the mammalian unfolded protein response

1 reference

12 December 2020