Hepatocyte growth factor-regulated tyrosine kinase substrate (Q21140280)

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mammalian protein found in Homo sapiens

Hrs
human growth factor-regulated tyrosine kinase substrate
HGS
protein pp110
hepatocyte growth factor-regulated tyrosine kinase substrate

Language	Label	Description	Also known as
English	Hepatocyte growth factor-regulated tyrosine kinase substrate	mammalian protein found in Homo sapiens	Hrs human growth factor-regulated tyrosine kinase substrate HGS protein pp110 hepatocyte growth factor-regulated tyrosine kinase substrate

Statements

1 reference

13 November 2019

UniProt protein ID

Zinc finger, FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Zinc finger, RING/FYVE/PHD-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Ubiquitin binding protein, Hrs/VPS27

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FYVE zinc finger, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, FYVE-related, protein family

1 reference

based on heuristic

inferred from protein domain or family

VHS domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ubiquitin interacting motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein domain specific binding

determination method

1 reference

8 April 2019

The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

protein binding

determination method

16 references

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Crystallographic and Functional Analysis of the ESCRT-I /HIV-1 Gag PTAP Interaction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Hybrid Structural Model of the Complete Human ESCRT-0 Complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Novel function of POSH, a JNK scaffold, as an E3 ubiquitin ligase for the Hrs stability on early endosomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Interactions of TOM1L1 with the multivesicular body sorting machinery

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

ubiquitin-like protein ligase binding

determination method

1 reference

8 April 2019

The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

early endosome membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

multivesicular body membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

intracellular membrane-bounded organelle

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

8 April 2019

The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

extracellular exosome

determination method

1 reference

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14964&geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

extracellular exosome

determination method

1 reference

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

biological process

protein localization to membrane

determination method

1 reference

8 April 2019

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

protein targeting to lysosome

determination method

1 reference

8 April 2019

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

negative regulation of epidermal growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

membrane invagination

determination method

1 reference

8 April 2019

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

multivesicular body assembly

determination method

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

positive regulation of gene expression

determination method

1 reference

8 April 2019

Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

regulation of protein catabolic process

determination method

1 reference

8 April 2019

Interactions of TOM1L1 with the multivesicular body sorting machinery

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

protein transport

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

regulation of MAP kinase activity

determination method

1 reference

8 April 2019

Vps22/EAP30 in ESCRT-II mediates endosomal sorting of growth factor and chemokine receptors destined for lysosomal degradation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

positive regulation of exosomal secretion

determination method

1 reference

8 April 2019

Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

intracellular protein transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

signal transduction

determination method

1 reference

8 April 2019

Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

negative regulation of cell population proliferation

determination method

1 reference

8 April 2019

Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

negative regulation of receptor signaling pathway via JAK-STAT

determination method

1 reference

8 April 2019

Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

8 April 2019

Membrane budding and scission by the ESCRT machinery: it's all in the neck

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

protein deubiquitination

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

membrane organization

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

determination method

1 reference

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O14964&geneProductId=UniProtKB:O14964

determination method

negative regulation of platelet-derived growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

negative regulation of angiogenesis

determination method

1 reference

8 April 2019

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

negative regulation of vascular endothelial growth factor receptor signaling pathway

determination method

1 reference

8 April 2019

miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O14964

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

FYVE zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Ubiquitin interacting motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Zinc finger, FYVE-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O14964

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000331201

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000331201

ENSP00000458603

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458603

ENSP00000458775

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458775

ENSP00000458789

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458789

ENSP00000458987

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000458987

ENSP00000459685

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000459685

ENSP00000460130

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460130

ENSP00000460165

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000460165

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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