Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling (Q24319849)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444102%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

title

Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling (English)

1 reference

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Hepatocyte growth factor-regulated tyrosine kinase substrate

15 December 2019

main subject

1 reference

GOA release 2020-03-11

neurofibromin 2

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signal transducer and activator of transcription 3

GOA release 2020-03-11

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neurofibromatosis type II

GOA release 2020-03-11

1 reference

5

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15 December 2019

David H. Gutmann

6

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15 December 2019

author name string

Daniel R Scoles

1

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15 December 2019

Vu D Nguyen

2

1 reference

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15 December 2019

Yun Qin

3

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15 December 2019

Chun-Xiao Sun

4

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15 December 2019

Stefan-M Pulst

7

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15 December 2019

language of work or name

English

0 references

publication date

1 December 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12444102%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

published in

Human Molecular Genetics

1 reference

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15 December 2019

volume

11

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15 December 2019

issue

25

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15 December 2019

page(s)

3179-3189

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Insulin-like growth factor I: a mitogen for rat Schwann cells in the presence of elevated levels of cyclic AMP

15 December 2019

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Merlin differentially associates with the microtubule and actin cytoskeleton

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Effects of Nf2 missense mutations on schwannomin interactions

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Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells.

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A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

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Hrs regulates endosome membrane invagination and tyrosine kinase receptor signaling in Drosophila

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STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction

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Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

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Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis

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Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes

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Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas

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Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

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Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

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Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

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Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins

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Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

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Rac1 mediates STAT3 activation by autocrine IL-6

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Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes

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7 January 2021

Hrs is associated with STAM, a signal-transducing adaptor molecule. Its suppressive effect on cytokine-induced cell growth

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7 January 2021

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

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7 January 2021

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

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7 January 2021

p21-activated kinase links Rac/Cdc42 signaling to merlin

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7 January 2021

Mechanism of STAT3 activation by insulin-like growth factor I receptor

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7 January 2021

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7 January 2021

Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

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Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

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7 January 2021

The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility

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7 January 2021

Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate

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7 January 2021

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Alternative transcripts in the mouse neurofibromatosis type 2 (NF2) gene are conserved and code for schwannomins with distinct C-terminal domains

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7 January 2021

Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading

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7 January 2021

The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate

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STATs and gene regulation

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7 January 2021

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A missense mutation in the neurofibromatosis 2 gene occurs in patients with mild and severe phenotypes

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7 January 2021

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