Mitogen-activated protein kinase kinase kinase 11 (Q21171701)

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mammalian protein found in Homo sapiens

protein-tyrosine kinase PTK1
mixed lineage kinase 3
SH3 domain-containing proline-rich kinase
MAP3K11
mitogen-activated protein kinase kinase kinase 11
src-homology 3 domain-containing proline-rich kinase

Language	Label	Description	Also known as
English	Mitogen-activated protein kinase kinase kinase 11	mammalian protein found in Homo sapiens	protein-tyrosine kinase PTK1 mixed lineage kinase 3 SH3 domain-containing proline-rich kinase MAP3K11 mitogen-activated protein kinase kinase kinase 11 src-homology 3 domain-containing proline-rich kinase

Statements

1 reference

13 November 2019

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

mitogen-activated protein (MAP) kinase kinase kinase, MLK1-4

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

MLK1-3, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

protein homodimerization activity

determination method

1 reference

8 April 2019

Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

mitogen-activated protein kinase kinase kinase binding

determination method

1 reference

8 April 2019

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

protein binding

determination method

4 references

8 April 2019

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

identical protein binding

determination method

1 reference

8 April 2019

Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

mitogen-activated protein kinase kinase binding

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

protein serine/threonine kinase activity

determination method

4 references

26 September 2017

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

26 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

26 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

26 September 2017

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

protein kinase activity

determination method

3 references

8 April 2019

MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper-basic region domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

JUN kinase kinase kinase activity

determination method

3 references

protein serine/threonine kinase activity

determination method

5 references

8 April 2019

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

26 September 2017

A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

26 September 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

microtubule organizing center

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

8 April 2019

A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

2 references

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

determination method

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

biological process

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

positive regulation of JUN kinase activity

determination method

1 reference

8 April 2019

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

positive regulation of JNK cascade

determination method

1 reference

8 April 2019

Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

positive regulation of neuron apoptotic process

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

microtubule-based process

determination method

1 reference

26 September 2017

A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q16584&geneProductId=UniProtKB:Q16584

determination method

cell population proliferation

determination method

1 reference

8 April 2019

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

protein phosphorylation

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

8 April 2019

The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q16584

determination method

microtubule-based process

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

serine/threonine-protein kinase, active site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

MLK1-3, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q16584

Identifiers

MeSH descriptor ID

subject named as

Mitogen-Activated Protein Kinase Kinase Kinase 11

0 references

D08.811.913.696.620.682.700.559.650

0 references

D12.776.476.563.554.650

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000309597

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000309597

ENSP00000433886

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433886

ENSP00000431506

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000431506

ENSP00000432068

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000432068

ENSP00000435237

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435237

ENSP00000435970

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435970

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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