Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3 (Q22008053)

protein homodimerization activity

GOA release 2020-03-11

1 reference

Journal of Biological Chemistry

GOA release 2020-03-11

I W Leung

1

I W

Leung

1 reference

7 February 2023

N Lassam

series ordinal

2

author given names

N

author last names

Lassam

1 reference

7 February 2023

language of work or name

English

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publication date

4 December 1998

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published in

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volume

273

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issue

49

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page(s)

32408-15

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cites work

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

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Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2

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Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

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Identification of a dual leucine zipper kinase involved in rat fracture repair.

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Cloning of a novel putative protein kinase having a leucine zipper domain from human brain

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Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

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High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer

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A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation

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Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe

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Leucine zipper-like domain regulates the autophosphorylation and the transforming activity of P130gag-fps

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Receptor signaling: dimerization and beyond

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Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin, and insulin-like growth factor I receptors.

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Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

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Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity

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7 January 2021