Sortilin 1 (Q21172409)

transporter of unknown biochemical mechanism

1 reference

Transporter Classification Database ID

9.A.63.1.3

retrieved

2 October 2019

hierarchical database ID heuristic

membrane protein

1 reference

inferred from GOA cell component → membrane

VPS10, protein family

1 reference

inferred from protein domain or family

Sortilin, C-terminal domain, protein family

1 reference

inferred from protein domain or family

Sortilin, N-terminal domain, protein family

1 reference

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

nerve growth factor receptor activity

1 reference

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

neurotensin receptor activity, non-G protein-coupled

1 reference

9 May 2019

The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

nerve growth factor binding

1 reference

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

11 references

9 May 2019

The role of ceroid lipofuscinosis neuronal protein 5 (CLN5) in endosomal sorting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Progranulin directly binds to the CRD2 and CRD3 of TNFR extracellular domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Golgi-localizing, gamma-adaptin ear homology domain, ADP-ribosylation factor-binding (GGA) proteins interact with acidic dileucine sequences within the cytoplasmic domains of sorting receptors through their Vps27p/Hrs/STAM (VHS) domains

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Multiple modification and protein interaction signals drive the Ring finger protein 11 (RNF11) E3 ligase to the endosomal compartment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

integral component of membrane

IPI

cell component

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

endoplasmic reticulum membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

intracellular membrane-bounded organelle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

5 references

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

Golgi cisterna membrane

1 reference

9 May 2019

1 reference

9 May 2019

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

endoplasmic reticulum

1 reference

9 May 2019

perinuclear region of cytoplasm

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

trans-Golgi network transport vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99523&geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

clathrin-coated vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

cytoplasmic vesicle membrane

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

integral component of membrane

IBA

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

G protein-coupled receptor signaling pathway

IBA

biological process

1 reference

9 May 2019

Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

negative regulation of fat cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

8 April 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

neurotrophin TRK receptor signaling pathway

1 reference

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

endosome transport via multivesicular body sorting pathway

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

endosome to lysosome transport

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

Golgi to endosome transport

1 reference

8 April 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

positive regulation of epithelial cell apoptotic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

plasma membrane to endosome transport

1 reference

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

regulation of gene expression

1 reference

9 May 2019

Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

negative regulation of lipoprotein lipase activity

IMP

1 reference

9 May 2019

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

neuropeptide signaling pathway

1 reference

9 May 2019

The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

extrinsic apoptotic signaling pathway via death domain receptors

1 reference

9 May 2019

Sortilin is essential for proNGF-induced neuronal cell death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

nerve growth factor signaling pathway

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

post-Golgi vesicle-mediated transport

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Sortilin is essential and sufficient for the formation of Glut4 storage vesicles in 3T3-L1 adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99523

1 reference

Sortilin, C-terminal

1 reference

Sortilin, N-terminal

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

Transporter Classification Database ID

English

9.A.63.1.3

2 references

Transporter Classification database

retrieved

13 March 2020