Fibroblast growth factor 21 (Q21172808)

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mammalian protein found in Homo sapiens

• FGF21
• fibroblast growth factor 21

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Language	Label	Description	Also known as
English	Fibroblast growth factor 21	mammalian protein found in Homo sapiens	FGF21 fibroblast growth factor 21

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NSA1

subclass of

protein

1 reference

stated in

UniProt

retrieved

1 December 2016

UniProt protein ID

Q9NSA1

part of

fibroblast growth factor 21

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9NSA1

Cytokine IL1/FGF

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q9NSA1

image

FGF21.png
1,920 × 975; 741 KB

0 references

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NSA1

encoded by

FGF21

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NSA1

molecular function

growth factor activity

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

protein binding

determination method

IPI

3 references

retrieved

8 April 2019

stated in

C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IPI

retrieved

8 April 2019

stated in

Different roles of N- and C- termini in the functional activity of FGF21

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IPI

retrieved

8 April 2019

stated in

FGF21 N- and C-termini play different roles in receptor interaction and activation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IPI

fibroblast growth factor receptor binding

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

cell component

extracellular region

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

extracellular space

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

biological process

endothelial cell apoptotic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

positive regulation of ERK1 and ERK2 cascade

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IDA

positive regulation of cell population proliferation

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

positive regulation of glucose import

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

GOA

curator

UniProt

UniProt protein ID

Q9NSA1

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IDA

cell-cell signaling

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

TAS

cellular response to glucose stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

fibroblast growth factor receptor signaling pathway

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

regulation of low-density lipoprotein particle clearance

determination method

NAS

1 reference

retrieved

8 April 2019

stated in

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)

GOA

curator

British Heart Foundation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

NAS

response to nutrient levels

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

negative regulation of endothelial cell apoptotic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

response to activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

signal transduction

determination method

TAS

1 reference

retrieved

8 April 2019

stated in

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

TAS

cellular response to low-density lipoprotein particle stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

endoplasmic reticulum unfolded protein response

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

negative regulation of neuron death

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

positive regulation of triglyceride catabolic process

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

response to methionine

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

cellular response to glucagon stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

regulation of signaling receptor activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

positive regulation of cold-induced thermogenesis

determination method

IEA

ISS

2 references

retrieved

8 April 2019

stated in

FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

GOA

curator

YuBioLab

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

ISS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NSA1

determination method

IEA

Identifiers

RefSeq protein ID

NP_061986

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

26291

UniProt protein ID

Q9NSA1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q9NSA1

Ensembl protein ID

ENSP00000222157

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000222157

ENSP00000471477

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000471477

PDB structure ID

5VAQ

found in taxon

Homo sapiens

0 references

6M6F

found in taxon

Homo sapiens

0 references

6M6E

found in taxon

Homo sapiens

0 references

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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