RhoA: a therapeutic target for chronic myeloid leukemia (Q21245760)

19 August 2022

Madhura B Pradhan

series ordinal

2

author given names

Madhura B

author last names

Pradhan

1 reference

19 August 2022

Suresh H Advani

series ordinal

3

author given names

Suresh H

author last names

Advani

1 reference

19 August 2022

Nishigandha R Naik

series ordinal

4

author given names

Nishigandha R

author last names

Naik

1 reference

Rho GTPases in hematopoiesis and hemopathies

19 August 2022

language of work or name

English

0 references

publication date

2012

0 references

published in

Molecular Cancer

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volume

11

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issue

1

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page(s)

16

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cites work

1 reference

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Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway

19 March 2017

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Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

19 March 2017

1 reference

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Rho GTPases and signaling networks

19 March 2017

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19 March 2017

RHO-GTPases and cancer

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An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1

7 April 2017

1 reference

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The RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation

7 April 2017

1 reference

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Differential role of an atypical protein kinase C, PKC zeta, in regulation of human eosinophil and neutrophil functions

12 September 2017

1 reference

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Rho GTPase expression in tumourigenesis: evidence for a significant link

12 September 2017

1 reference

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Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation

12 September 2017

1 reference

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Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation

12 September 2017

1 reference

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12 September 2017

Rho proteins and cancer

1 reference

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Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma.

12 September 2017

1 reference

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Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters

12 September 2017

1 reference

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The role of Rho GTPases in disease development

12 September 2017

1 reference

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Overexpression of wild-type RhoA produces growth arrest by disrupting actin cytoskeleton and microtubules

12 September 2017

1 reference

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The Ras family of GTPases in cancer cell invasion.

12 September 2017

1 reference

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Rhythmic patterns in the expression of the ras oncogene in proliferating and differentiating erythroleukaemia cells

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Differences in the microtubule organization between normal and cml granulocytes after stimulation with chemotactic peptide

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Viability measurements in mammalian cell systems

12 September 2017

1 reference

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Differential motility of p190bcr-abl- and p210bcr-abl-expressing cells: respective roles of Vav and Bcr-Abl GEFs

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells.

27 September 2017

1 reference

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Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Global effects of BCR/ABL and TEL/PDGFRbeta expression on the proteome and phosphoproteome: identification of the Rho pathway as a target of BCR/ABL.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Analysis of Gene Expression Profiles in an Imatinib‐Resistant Cell Line, KCL22/SR

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Rac downregulates Rho activity: reciprocal balance between both GTPases determines cellular morphology and migratory behavior

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K.

27 September 2017

1 reference

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An actin-binding function contributes to transformation by the Bcr-Abl oncoprotein of Philadelphia chromosome-positive human leukemias

27 September 2017

1 reference

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The jun and fos protein families are both required for cell cycle progression in fibroblasts

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL.

27 September 2017

1 reference

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Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

p38 MAPK-mediated activation of NF-kappaB by the RhoGEF domain of Bcr.

30 May 2018

1 reference

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30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

The GTP-binding protein Rho.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

PMN cells from chronic myeloid leukemia (CML) patients show defective chemotaxis in remission

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Chemoattractant receptor-stimulated F-actin polymerization in the human neutrophil is signaled by 2 distinct pathways

30 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Small GTPase Rac1: structure, localization, and expression of the human gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Rho GTPases are over-expressed in human tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Historical overview of Rho GTPases

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Reduced oncogenicity of p190 Bcr/Abl F-actin-binding domain mutants.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3353160

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

29 November 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-11-16

Separation of blood leucocytes, granulocytes and lymphocytes

21 January 2018

1 reference

12 December 2020

Flow cytometric studies on actin polymerization in PMN cells from chronic myeloid leukemia (CML) patients

1 reference

12 December 2020

Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin

1 reference

12 December 2020

Chronic myeloid leukemia granulocytes have lower amounts of cytoplasmic actin

1 reference

12 December 2020

Granulocytes from chronic myeloid leukemia (CML) patients show differential response to different chemoattractants

1 reference

12 December 2020

Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

1 reference

12 December 2020

Correlation between RhoA overexpression and tumour progression in esophageal squamous cell carcinoma

1 reference

12 December 2020

Actin polymerization in response to different chemoattractants is reduced in granulocytes from chronic myeloid leukemia patients

1 reference

12 December 2020

Identifiers

DOI

10.1186/1476-4598-11-16

1 reference

https://scigraph.springernature.com/pub.10.1186/1476-4598-11-16

1 reference

9 September 2019

1 reference

1 reference

PubMed publication ID

22443473

1 reference