RHO-GTPases and cancer (Q29616099)

Europe PubMed Central

title

RHO-GTPases and cancer (English)

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30 April 2017

author name string

Sahai E

series ordinal

1

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30 April 2017

Marshall CJ

series ordinal

2

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12635176

30 April 2017

language of work or name

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30 April 2017

publication date

February 2002

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30 April 2017

published in

Nature Reviews Cancer

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30 April 2017

volume

2

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30 April 2017

issue

2

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30 April 2017

page(s)

133-42

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Initial sequencing and analysis of the human genome

30 April 2017

cites work

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Rho GTPases and the actin cytoskeleton

1 May 2017

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Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth

1 May 2017

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Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

1 May 2017

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia

1 May 2017

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Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA

1 May 2017

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Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

1 May 2017

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RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

1 May 2017

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Asef, a link between the tumor suppressor APC and G-protein signaling

1 May 2017

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Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1

1 May 2017

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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

1 May 2017

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Genomic analysis of metastasis reveals an essential role for RhoC

1 May 2017

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A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion

1 May 2017

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

1 May 2017

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Role of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape change

1 May 2017

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AP-1 in cell proliferation and survival

1 May 2017

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 May 2017

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The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

1 May 2017

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A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCzeta signaling and cell transformation

1 May 2017

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Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

1 May 2017

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Synaptojanin 2, a novel Rac1 effector that regulates clathrin-mediated endocytosis

1 May 2017

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Interaction of the Rho family small G proteins with kinectin, an anchoring protein of kinesin motor

1 May 2017

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Kinectin is a key effector of RhoG microtubule-dependent cellular activity

1 May 2017

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Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

1 May 2017

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

1 May 2017

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RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

1 May 2017

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RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

1 May 2017

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The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

1 May 2017

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Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42

1 May 2017

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PIST: a novel PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10

1 May 2017

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

1 May 2017

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Rho GTPases and their effector proteins

1 May 2017

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Rho GTPases and signaling networks

31 March 2020

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A role for Rho in Ras transformation

31 March 2020

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An essential role for Rac in Ras transformation

31 March 2020

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Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

31 March 2020

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The small GTPases Cdc42Hs, Rac1 and RhoG delineate Raf-independent pathways that cooperate to transform NIH3T3 cells

31 March 2020

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Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation

31 March 2020

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The Dbl homology domain of BCR is not a simple spacer in P210BCR-ABL of the Philadelphia chromosome

31 March 2020

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Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma

31 March 2020

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Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour

31 March 2020

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Rho GTPases are over-expressed in human tumors.

31 March 2020

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Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

31 March 2020

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Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b

31 March 2020

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Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors

31 March 2020

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Oncogenic Ras downregulates Rac activity, which leads to increased Rho activity and epithelial-mesenchymal transition

31 March 2020

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Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation

31 March 2020

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Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering

31 March 2020

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Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism

31 March 2020

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Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1

31 March 2020

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Multiple roles of the Dcdc42 GTPase during wing development in Drosophila melanogaster.

31 March 2020

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Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton.

31 March 2020

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A novel Cdc42Hs mutant induces cellular transformation

31 March 2020

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The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

31 March 2020

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Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

31 March 2020

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Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

31 March 2020

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An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.

31 March 2020

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Inhibitory effect of Y-27632, a ROCK inhibitor, on progression of rat liver fibrosis in association with inactivation of hepatic stellate cells

31 March 2020

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Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells

31 March 2020

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RhoE regulates actin cytoskeleton organization and cell migration.

31 March 2020

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Induced expression of Rnd3 is associated with transformation of polarized epithelial cells by the Raf-MEK-extracellular signal-regulated kinase pathway

31 March 2020

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Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly

31 March 2020

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Cell polarity: new PARtners for Cdc42 and Rac

31 March 2020

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Activation of the small GTPase Rac is sufficient to disrupt cadherin-dependent cell-cell adhesion in normal human keratinocytes

31 March 2020

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Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation

31 March 2020

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Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

31 March 2020

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

31 March 2020

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High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential

31 March 2020

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Mortality association of enhanced CD44v6 expression is not mediated through occult lymphatic spread in stage II colorectal cancer

31 March 2020

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Introduction of antisense CD44S CDNA down-regulates expression of overall CD44 isoforms and inhibits tumor growth and metastasis in highly metastatic colon carcinoma cells

31 March 2020

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

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Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrier

31 March 2020

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Rac affects invasion of human renal cell carcinomas by up-regulating tissue inhibitor of metalloproteinases (TIMP)-1 and TIMP-2 expression

31 March 2020

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Small GTP-binding protein, Rho, both increased and decreased cellular motility, activation of matrix metalloproteinase 2 and invasion of human osteosarcoma cells

31 March 2020

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RhoA is required for monocyte tail retraction during transendothelial migration

31 March 2020

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RhoC GTPase overexpression modulates induction of angiogenic factors in breast cells

31 March 2020

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Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42.

31 March 2020

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CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

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Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo

31 March 2020

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Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions

31 March 2020

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NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition

31 March 2020

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Rho family members: activators of MAP kinase cascades.

31 March 2020

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Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

31 March 2020

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Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

31 March 2020

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The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF

31 March 2020

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The AP-1 site and MMP gene regulation: what is all the fuss about?

31 March 2020

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Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

31 March 2020

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Timing of cyclin D1 expression within G1 phase is controlled by Rho.

31 March 2020

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Rho effectors and reorganization of actin cytoskeleton

31 March 2020

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Fibronectin, integrins, and growth control

31 March 2020

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Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression.

31 March 2020

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Suppression of Ras-induced apoptosis by the Rac GTPase

31 March 2020

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Integration of Rac-dependent regulation of cyclin D1 transcription through a nuclear factor-kappaB-dependent pathway

31 March 2020

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Dbl and the Rho GTPases activate NF kappa B by I kappa B kinase (IKK)-dependent and IKK-independent pathways

31 March 2020

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Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1.

31 March 2020

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Activation of IkappaB kinase beta by protein kinase C isoforms

31 March 2020

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Rel/NF-kappa B transcription factors and the control of apoptosis

31 March 2020

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Integrin-Specific Activation of Rac Controls Progression through the G1 Phase of the Cell Cycle

31 March 2020

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Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

31 March 2020

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Transformation mediated by RhoA requires activity of ROCK kinases

31 March 2020

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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

31 March 2020

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

31 March 2020

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Ras-stimulated extracellular signal-related kinase 1 and RhoA activities coordinate platelet-derived growth factor-induced G1 progression through the independent regulation of cyclin D1 and p27

31 March 2020

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Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes. Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression

31 March 2020

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Regulation of c-myc expression by PDGF through Rho GTPases.

31 March 2020

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The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation

31 March 2020

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Regulation of receptor-mediated endocytosis by Rho and Rac.

31 March 2020

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Endosome dynamics regulated by a Rho protein.

31 March 2020

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A MAP kinase-dependent actin checkpoint ensures proper spindle orientation in fission yeast

31 March 2020

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Cadherin engagement regulates Rho family GTPases

31 March 2020

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Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression

31 March 2020

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Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

31 March 2020

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Activation of the RacGTPase inhibits apoptosis in human tumor cells

31 March 2020

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Rac1 protects epithelial cells against anoikis

31 March 2020

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The Akt proto-oncogene links Ras to Pak and cell survival signals

31 March 2020

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Rac2 stimulates Akt activation affecting BAD/Bcl-XL expression while mediating survival and actin function in primary mast cells

31 March 2020

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The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis

31 March 2020

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Actin' up: RhoB in cancer and apoptosis

31 March 2020

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Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas.

31 March 2020

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Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153

31 March 2020

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Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors.

31 March 2020

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Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.

31 March 2020

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Brefeldin A: the advantage of being uncompetitive

31 March 2020

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Inhibition of Ras and related guanosine triphosphate-dependent proteins as a therapeutic strategy for blocking malignant glioma growth: II--preclinical studies in a nude mouse model.

31 March 2020

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

31 March 2020

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Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.

31 March 2020

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Chp, a homologue of the GTPase Cdc42Hs, activates the JNK pathway and is implicated in reorganizing the actin cytoskeleton

31 March 2020

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31 March 2020

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Tiam1 mutations in human renal-cell carcinomas

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12635176

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

1526452

1022902509

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1526452

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12635176

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017