Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? (Q21245770)

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11 February 2020

review article

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8 February 2021

17 February 2023

Messing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer? (English)

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11 February 2020

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14 September 2019

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8 February 2021

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PubMed publication ID

1

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11 February 2020

David P Minde

series ordinal

2

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11 February 2020

4

Stefan Gd Rüdiger

Stefan Gd

Rüdiger

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11 February 2020

5

Madelon M Maurice

Madelon M

Maurice

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11 February 2020

Zeinab Anvarian

3

Zeinab

Anvarian

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11 February 2020

language of work or name

English

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publication date

22 August 2011

7 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

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11 February 2020

8 February 2021

17 February 2023

7 references

3 April 2019

20 June 2019

30 June 2019

14 September 2019

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11 February 2020

8 February 2021

17 February 2023

10

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1

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page(s)

101

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Creative Commons Attribution 2.0 Generic

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copyright license

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Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours

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Somatic mutations of adenomatous polyposis coli gene and nuclear b-catenin accumulation have prognostic significance in invasive urothelial carcinomas: evidence for Wnt pathway implication

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Axin, an inhibitor of the Wnt signalling pathway, interacts with beta-catenin, GSK-3beta and APC and reduces the beta-catenin level

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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12 September 2017

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27 September 2017

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The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

27 September 2017

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Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.

27 September 2017

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The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF.

27 September 2017

1 reference

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Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin

27 September 2017

1 reference

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Helix design, prediction and stability

27 September 2017

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Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

27 September 2017

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The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis

30 May 2018

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Germline mutations of the APC gene in two Japanese adenomatous polyposis patients.

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Chemical dissection of the APC Repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3.

21 January 2018

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Disorder-order folding transitions underlie catalysis in the helicase motor of SecA

21 January 2018

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Multiple rare nonsynonymous variants in the adenomatous polyposis coli gene predispose to colorectal adenomas.

21 January 2018

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Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation

29 November 2018

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Tuning bulk electrostatics to regulate protein function

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The chicken-egg scenario of protein folding revisited

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Identifiers

DOI

10.1186/1476-4598-10-101

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21859464%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 February 2020

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1476-4598-10-101

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21859464%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

PubMed publication ID

21859464

2 references