Medicinal importance of grapefruit juice and its interaction with various drugs (Q21245902)

cytochrome P-450 enzyme inhibitors

20 August 2019

1 reference

2 October 2019

1 reference

22 October 2019

1 reference

26 October 2020

Jawad Kiani

1

Jawad

Kiani

1 reference

Dimensions Publication ID

Dimensions

1023171374

19 August 2022

Sardar Z Imam

series ordinal

2

author given names

Sardar Z

author last names

Imam

1 reference

Dimensions Publication ID

Dimensions

1023171374

Creative Commons Attribution 2.0 Generic

19 August 2022

language of work or name

English

0 references

publication date

30 October 2007

5 references

9 August 2019

20 August 2019

2 October 2019

22 October 2019

26 October 2020

2007

0 references

5 references

9 August 2019

20 August 2019

2 October 2019

22 October 2019

26 October 2020

6

0 references

issue

1

0 references

page(s)

33

0 references

copyright license

5 references

9 August 2019

20 August 2019

2 October 2019

22 October 2019

https://scigraph.springernature.com/pub.10.1186/1475-2891-6-33

26 October 2020

0 references

0 references

cites work

Grapefruit juice-drug interactions

1 reference

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Undesirable effects of citrus juice on the pharmacokinetics of drugs: focus on recent studies

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

19 March 2017

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Interactions between grapefruit juice and cardiovascular drugs

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Time course of recovery of cytochrome p450 3A function after single doses of grapefruit juice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Coadministration of grapefruit juice increases systemic exposure of diltiazem in healthy volunteers

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Stereoselective pharmacokinetics of cisapride in healthy volunteers and the effect of repeated administration of grapefruit juice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

The effects of grapefruit juice on sertraline metabolism: an in vitro and in vivo study

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice substantially increases plasma concentrations of buspirone

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Relationship between time of intake of grapefruit juice and its effect on pharmacokinetics and pharmacodynamics of felodipine in healthy subjects

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

The effects of fruit juices on drug disposition: a new model for drug interactions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of grapefruit juice intake on etoposide bioavailability

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Intestinal first pass metabolism of midazolam in liver cirrhosis --effect of grapefruit juice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Single-dose pharmacokinetics of amprenavir coadministered with grapefruit juice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effects of grapefruit juice and smoking on verapamil concentrations in steady state

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Drug-grapefruit juice interactions

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effects of repeated ingestion of grapefruit juice on the single and multiple oral-dose pharmacokinetics and pharmacodynamics of alprazolam

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice has minimal effects on plasma concentrations of lovastatin-derived 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Different effects of itraconazole on the pharmacokinetics of fluvastatin and lovastatin

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice enhances the bioavailability of the HIV protease inhibitor saquinavir in man

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of grapefruit juice on clarithromycin pharmacokinetics

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effects of grapefruit juice ingestion--pharmacokinetics and haemodynamics of intravenously and orally administered felodipine in healthy men.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Naringin and naringenin are not the primary CYP3A inhibitors in grapefruit juice

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Interaction of citrus juices with felodipine and nifedipine

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2.

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Interaction between grapefruit juice and praziquantel in humans.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Characterization of human small intestinal cytochromes P-450.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of Seville orange juice and grapefruit juice on indinavir pharmacokinetics

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Dramatic inhibition of amiodarone metabolism induced by grapefruit juice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Pharmacokinetic analysis of felodipine-grapefruit juice interaction based on an irreversible enzyme inhibition model

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice activates P-glycoprotein-mediated drug transport

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Drug interactions with grapefruit juice. Extent, probable mechanism and clinical relevance

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Excessive terfenadine level due to drinking grapefruit juice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice does not enhance the effects of midazolam and triazolam in man.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Ethanol enhances the hemodynamic effects of felodipine.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Interaction between grapefruit juice and midazolam in humans.

30 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Effects of grapefruit juice on pharmacokinetic exposure to indinavir in HIV-positive subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

The effect of grapefruit juice on the time-dependent decline of artemether plasma levels in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Red wine-cisapride interaction: comparison with grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Effect of grapefruit juice on cyclosporin A pharmacokinetics in pediatric renal transplant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1475-2891-6-33

Grapefruit juice and drugs: a hazardous combination?

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Intake of grapefruit juice alters the metabolic pattern of cyclosporin A in renal transplant recipients.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Effect of grapefruit juice or cimetidine coadministration on albendazole bioavailability

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Repeated ingestion of grapefruit juice does not alter clozapine's steady-state plasma levels, effectiveness, and tolerability.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Oral midazolam-grapefruit juice drug interaction

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

In vitro inhibition of midazolam and quinidine metabolism by flavonoids.

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2147024

Grapefruit-felodipine interaction: effect of unprocessed fruit and probable active ingredients

29 November 2018

1 reference

12 December 2020

Variance of common flavonoids by brand of grapefruit juice

1 reference

12 December 2020

Grapefruit juice--felodipine interaction: mechanism, predictability, and effect of naringin

1 reference

12 December 2020

Effect of grapefruit juice and naringin on nisoldipine pharmacokinetics

1 reference

12 December 2020

Inhibition of atherosclerosis by dietary pectin in microswine with sustained hypercholesterolemia

1 reference

12 December 2020

Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects

1 reference

12 December 2020

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

1 reference

12 December 2020

Grapefruit juice alters the systemic bioavailability and cardiac repolarization of terfenadine in poor metabolizers of terfenadine

1 reference

12 December 2020

Dosing implications of a clinical interaction between grapefruit juice and cyclosporine and metabolite concentrations in patients with autoimmune diseases

1 reference

12 December 2020

Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance

1 reference

12 December 2020

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole

1 reference

12 December 2020

Plasma buspirone concentrations are greatly increased by erythromycin and itraconazole

1 reference

12 December 2020

Specific CYP3A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

1 reference

12 December 2020

Interaction between cyclosporine and grapefruit juice requires long-term ingestion in stable renal transplant recipients

1 reference

12 December 2020

Grapefruit juice increases oral nimodipine bioavailability

1 reference

12 December 2020

Grapefruit juice-felodipine interaction: effect of naringin and 6',7'-dihydroxybergamottin in humans

1 reference

12 December 2020

Inhibition of mammary cancer by citrus flavonoids

1 reference

12 December 2020

6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein

1 reference

12 December 2020

Lack of significant pharmacokinetic interaction between haloperidol and grapefruit juice

1 reference

12 December 2020

Grapefruit juice has no effect on quinine pharmacokinetics

1 reference

12 December 2020

Grapefruit juice increases the bioavailability of artemether

1 reference

12 December 2020

Repeated consumption of grapefruit juice considerably increases plasma concentrations of cisapride

1 reference

12 December 2020

Lack of pharmacokinetic interaction between grapefruit juice and phenytoin in healthy male volunteers and epileptic patients

1 reference

12 December 2020

Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects

1 reference

12 December 2020

Role of furanocoumarin derivatives on grapefruit juice-mediated inhibition of human CYP3A activity

1 reference

12 December 2020

Grapefruit juice--felodipine interaction in the elderly

1 reference

12 December 2020