5'-3' exoribonuclease 1 (Q21245962)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8IZH2

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Putative 5-3 exonuclease family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

protein binding

6 references

8 April 2019

Exonuclease hDIS3L2 specifies an exosome-independent 3'-5' degradation pathway of human cytoplasmic mRNA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

nucleic acid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

nuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

RNA binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IZH2&geneProductId=UniProtKB:Q8IZH2

3 references

26 September 2017

26 September 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IZH2&geneProductId=UniProtKB:Q8IZH2

26 September 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IZH2&geneProductId=UniProtKB:Q8IZH2

G-quadruplex RNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

ISS

G-quadruplex DNA binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

ISS

telomerase RNA binding

1 reference

8 April 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

5'-3' exonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

RNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

3 references

8 April 2019

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

cell component

membrane

1 reference

26 September 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8IZH2&geneProductId=UniProtKB:Q8IZH2

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

nucleus

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

neuronal cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

P-body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

membrane

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

regulation of mRNA stability

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

1 reference

8 April 2019

TAS

rRNA catabolic process

1 reference

8 April 2019

Addition of poly(A) and poly(A)-rich tails during RNA degradation in the cytoplasm of human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

nuclear mRNA surveillance

1 reference

8 April 2019

Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

histone mRNA catabolic process

1 reference

8 April 2019

Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

negative regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

response to testosterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

cellular response to cycloheximide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

RNA phosphodiester bond hydrolysis, exonucleolytic

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

cellular response to puromycin

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

negative regulation of telomere maintenance via telomerase

1 reference

8 April 2019

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

GOA

curator

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8IZH2

has part(s)

Putative 5-3 exonuclease

1 reference

InterPro Release 71.0