Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL (Q21284163)

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15 January 2020

title

Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL (English)

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15 January 2020

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1

Andrew Macdonald

Andrew

Macdonald

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15 January 2020

6

J Simon C Arthur

J Simon C

Arthur

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15 January 2020

David G Campbell

2

David G

Campbell

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15 January 2020

Rachel Toth

series ordinal

3

author given names

Rachel

author last names

Toth

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15 January 2020

Hilary McLauchlan

series ordinal

4

author given names

Hilary

author last names

McLauchlan

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15 January 2020

C James Hastie

series ordinal

5

author given names

C James

author last names

Hastie

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15 January 2020

language of work or name

English

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publication date

10 January 2006

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15 January 2020

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15 January 2020

volume

7

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issue

1

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page(s)

1

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https://scigraph.springernature.com/pub.10.1186/1471-2121-7-1

15 January 2020

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cites work

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14-3-3 inhibits Bad-induced cell death through interaction with serine-136

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

19 March 2017

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

19 March 2017

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Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by Pim-1 kinase

19 March 2017

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Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

19 March 2017

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Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity

19 March 2017

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14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation

19 March 2017

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BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival

19 March 2017

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Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

19 March 2017

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The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

19 March 2017

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

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19 March 2017

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12 September 2017

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12 September 2017

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12 September 2017

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27 September 2017

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27 September 2017

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HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals

27 September 2017

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27 September 2017

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Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

27 September 2017

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Enforced expression of the Mr 33,000 Pim-1 kinase enhances factor-independent survival and inhibits apoptosis in murine myeloid cells

27 September 2017

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Pim-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation

27 September 2017

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Proviral activation of the putative oncogene Pim-1 in MuLV induced T-cell lymphomas

27 September 2017

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Identification of protein phosphorylation sites by a combination of mass spectrometry and solid phase Edman sequencing

27 September 2017

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Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin.

30 May 2018

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Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

30 May 2018

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The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases.

30 May 2018

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Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site

30 May 2018

1 reference

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Pim-1 phosphorylates the DNA binding domain of c-Myb.

29 November 2018

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Pim-1 protein kinase is nuclear in Burkitt's lymphoma: nuclear localization is necessary for its biologic effects.

29 November 2018

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Cdc2 phosphorylation of BAD links the cell cycle to the cell death machinery

29 November 2018

1 reference

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Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors

29 November 2018

1 reference

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Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras

29 November 2018

1 reference

12 December 2020

Assignment of the human homologue of Pim-1, a mouse gene implicated in leukemogenesis, to the pter-q12 region of chromosome 6

1 reference

12 December 2020

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

1 reference

12 December 2020

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

1 reference

12 December 2020

Identifiers

DOI

10.1186/1471-2121-7-1

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16403219%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 January 2020

1022909103

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16403219%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

2 references