HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals (Q40770875)

23 September 2017

HIV-1 Nef associated PAK and PI3-kinases stimulate Akt-independent Bad-phosphorylation to induce anti-apoptotic signals (English)

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23 September 2017

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Wolf D

1

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23 September 2017

Witte V

2

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23 September 2017

Laffert B

3

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23 September 2017

Blume K

4

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23 September 2017

Stromer E

5

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23 September 2017

Trapp S

6

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23 September 2017

d'Aloja P

7

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23 September 2017

Schürmann A

8

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23 September 2017

Baur AS

9

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23 September 2017

language of work or name

English

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publication date

1 November 2001

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23 September 2017

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23 September 2017

7

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23 September 2017

1217-1224

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23 September 2017

11

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https://scigraph.springernature.com/pub.10.1038/nm1101-1217

23 September 2017

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cites work

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Interactions of HIV-1 NEF with cellular signal transducing proteins

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

The N-Terminus of Nef from HIV-1/SIV Associates with a Protein Complex Containing Lck and a Serine Kinase

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Identification of the Nef-associated kinase as p21-activated kinase 2

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

p21-activated protein kinase: a crucial component of morphological signaling?

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

BCL-2 family members and the mitochondria in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

The HIV-1 nef protein interferes with phosphatidylinositol 3-kinase activation 1.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Cellular survival: a play in three Akts

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Role of translocation in the activation and function of protein kinase B

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Regulation of protein kinase B in rat adipocytes by insulin, vanadate, and peroxovanadate. Membrane translocation in response to peroxovanadate

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

CDC42 and Rac1 are implicated in the activation of the Nef-associated kinase and replication of HIV-1.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

The C-terminal SH2 domain of p85 accounts for the high affinity and specificity of the binding of phosphatidylinositol 3-kinase to phosphorylated platelet-derived growth factor beta receptor

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Anti-apoptotic strategies of lymphotropic viruses

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Regulation of apoptosis by viral gene products

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Functional and structural defects in HIV type 1 nef genes derived from pediatric long-term survivors.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Bad can act as a key regulator of T cell apoptosis and T cell development.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Lentivirus Nef specifically activates Pak2.

1 reference

https://api.crossref.org/works/10.1038%2FNM1101-1217

7 January 2021

Identifiers

DOI

10.1038/NM1101-1217

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Dimensions Publication ID

23 September 2017

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1 reference