Hepatitis A virus cellular receptor 2 (Q21418776)

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mammalian protein found in Mus musculus

TIM-3
T-cell immunoglobulin mucin receptor 3
TIMD-3
hepatitis A virus cellular receptor 2 homolog
T-cell membrane protein 3
HAVcr-2
Havcr2
T-cell immunoglobulin and mucin domain containing 3
T-cell immunoglobulin and mucin domain-containing protein 3

Language	Label	Description	Also known as
English	Hepatitis A virus cellular receptor 2	mammalian protein found in Mus musculus	TIM-3 T-cell immunoglobulin mucin receptor 3 TIMD-3 hepatitis A virus cellular receptor 2 homolog T-cell membrane protein 3 HAVcr-2 Havcr2 T-cell immunoglobulin and mucin domain containing 3 T-cell immunoglobulin and mucin domain-containing protein 3

Statements

1 reference

25 May 2022

UniProt protein ID

Immunoglobulin-like fold

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VIM0

Immunoglobulin-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VIM0

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

based on heuristic

inferred from protein domain or family

Immunoglobulin V-set domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

immunoglobulin-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

protein binding

determination method

3 references

14 February 2019

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

integral component of membrane

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

plasma membrane

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

extracellular region

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

immunological synapse

determination method

1 reference

14 February 2019

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

mediator complex

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

biological process

negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of defense response to bacterium

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of immunological synapse formation

determination method

1 reference

14 February 2019

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

adaptive immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

maternal process involved in female pregnancy

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of cytokine production

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of natural killer cell activation

determination method

1 reference

14 February 2019

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

immune system process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of immune response to tumor cell

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of interleukin-6 production

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of interferon-gamma production

determination method

1 reference

14 February 2019

Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of macrophage activation

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

regulation of tolerance induction dependent upon immune response

determination method

1 reference

14 February 2019

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of T-helper 1 type immune response

determination method

1 reference

14 February 2019

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of defense response to bacterium

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of NIK/NF-kappaB signaling

determination method

1 reference

14 February 2019

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

macrophage activation involved in immune response

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of T cell proliferation

determination method

1 reference

14 February 2019

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of T cell proliferation

determination method

1 reference

14 February 2019

Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

14 February 2019

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of innate immune response

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of innate immune response

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of chemokine production

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of type I interferon production

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

toll-like receptor 9 signaling pathway

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

innate immune response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

inflammatory response

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

toll-like receptor 3 signaling pathway

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

cellular response to lipopolysaccharide

determination method

1 reference

14 February 2019

Tim-3 negatively mediates natural killer cell function in LPS-induced endotoxic shock

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

positive regulation of interleukin-1 production

determination method

1 reference

14 February 2019

Tim3 binding to galectin-9 stimulates antimicrobial immunity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

toll-like receptor 7 signaling pathway

determination method

1 reference

14 February 2019

Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

defense response to Gram-positive bacterium

determination method

1 reference

14 February 2019

Tim-3 directly enhances CD8 T cell responses to acute Listeria monocytogenes infection

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of interleukin-2 production

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

negative regulation of interferon-gamma production

determination method

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8VIM0

determination method

immunoglobulin subtype

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VIM0

immunoglobulin V-set domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VIM0

immunoglobulin-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8VIM0

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000020668

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000020668

ENSMUSP00000104852

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000104852

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

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