T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases (Q28510998)

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English	T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases	scientific journal article

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scholarly article

1 reference

25 January 2017

T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases (English)

1 reference

25 January 2017

Hepatitis A virus cellular receptor 2

1 reference

GOA release 2020-03-11

4

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11 June 2020

Lishomwa Ndhlovu

6

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11 June 2020

author name string

Kiera L Clayton

1

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11 June 2020

Matthew S Haaland

2

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11 June 2020

Matthew B Douglas-Vail

3

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11 June 2020

Glen M Chew

5

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11 June 2020

Mario A Ostrowski

7

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11 June 2020

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publication date

15 January 2014

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25 January 2017

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10

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Journal of Immunology

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25 January 2017

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11 June 2020

192

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11 June 2020

2

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11 June 2020

782-791

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11 June 2020

describes a project that uses

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11 June 2022

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Molecular mechanisms of T cell co-stimulation and co-inhibition

1 reference

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19 March 2017

The blockade of immune checkpoints in cancer immunotherapy

1 reference

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19 March 2017

Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry

1 reference

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19 March 2017

Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells

1 reference

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19 March 2017

T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface

1 reference

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19 March 2017

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9

1 reference

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19 March 2017

The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity

1 reference

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19 March 2017

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

1 reference

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19 March 2017

Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy

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29 September 2017

TIM-3 does not act as a receptor for galectin-9.

1 reference

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29 September 2017

Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion.

1 reference

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29 September 2017

Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection

1 reference

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29 September 2017

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.

1 reference

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29 September 2017

Role of LAT in the granule-mediated cytotoxicity of CD8 T cells

1 reference

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29 September 2017

Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity

1 reference

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29 September 2017

Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization

1 reference

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29 September 2017

Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways.

1 reference

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Dysregulation of TIM-3-galectin-9 pathway in the cystic fibrosis airways

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29 September 2017

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

1 reference

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29 September 2017

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214929

29 September 2017

TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity

1 reference

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29 September 2017

CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development

1 reference

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29 September 2017

A new type of membrane raft-like microdomains and their possible involvement in TCR signaling.

1 reference

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29 September 2017

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B.

1 reference

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29 September 2017

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

1 reference

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29 September 2017

Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells

1 reference

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29 September 2017

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

1 reference

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29 September 2017

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

1 reference

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29 September 2017

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection.

1 reference

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29 September 2017

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

1 reference

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29 September 2017

Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug

1 reference

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29 September 2017

Analysis of protein complexes using mass spectrometry

1 reference

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29 September 2017

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214929

29 September 2017

Immunological synapse and microclusters: the site for recognition and activation of T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214929

29 September 2017

Lipid rafts in T cell receptor signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4214929

29 September 2017

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment

1 reference

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29 September 2017

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease

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29 September 2017

Lck, Membrane Microdomains, and TCR Triggering Machinery: Defining the New Rules of Engagement

1 reference

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2 June 2018

Initiation of TCR phosphorylation and signal transduction

1 reference

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2 June 2018

LFA-1 regulates CD8+ T cell activation via T cell receptor-mediated and LFA-1-mediated Erk1/2 signal pathways

1 reference

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2 June 2018

Blockade of Tim-3 signaling restores the virus-specific CD8⁺ T-cell response in patients with chronic hepatitis B.

1 reference

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Antigen-independent induction of Tim-3 expression on human T cells by the common γ-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway

1 reference

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27 November 2018

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

1 reference

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27 November 2018

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses.

1 reference

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27 November 2018

Wiskott-Aldrich syndrome protein regulates lipid raft dynamics during immunological synapse formation.

1 reference

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27 November 2018

Galectin-9 inhibits CD44-hyaluronan interaction and suppresses a murine model of allergic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down-regulation of interleukin-2 production by CD4(+) T cells expressing TIM-3 through suppression of NFAT dephosphorylation and AP-1 transcription

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24337741

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4049/JIMMUNOL.1302663

1 reference

Europe PubMed Central

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11 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337741%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

2 references

25 January 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24337741%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

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