Cell division cycle 20 (Q21422912)

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mammalian protein found in Homo sapiens
  • CDC20
  • p55CDC
  • CDC20 cell division cycle 20 homolog
  • cell division cycle protein 20 homolog
  • cell division cycle 20 homolog
  • Cdc20 Proteins
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Language Label Description Also known as
English
Cell division cycle 20
mammalian protein found in Homo sapiens
  • CDC20
  • p55CDC
  • CDC20 cell division cycle 20 homolog
  • cell division cycle protein 20 homolog
  • cell division cycle 20 homolog
  • Cdc20 Proteins

Statements

molecular function
protein binding
determination method
IPI
34 references
retrieved
8 April 2019
stated in
MAD2B is an inhibitor of the anaphase-promoting complex
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
CDK5RAP2 is required for spindle checkpoint function
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression
GOA
curator
UniProt
UniProt protein ID
Q12834
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Evidence that Aurora B is implicated in spindle checkpoint signalling independently of error correction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Determinants of conformational dimerization of Mad2 and its inhibition by p31comet
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
ATP is required for the release of the anaphase-promoting complex/cyclosome from inhibition by the mitotic checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
The influence of catalysis on mad2 activation dynamics
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Probing the in vivo function of Mad1:C-Mad2 in the spindle assembly checkpoint
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
p31comet Promotes disassembly of the mitotic checkpoint complex in an ATP-dependent process
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Systematic analysis of human protein complexes identifies chromosome segregation proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Cell cycle control of Wnt/β-catenin signalling by conductin/axin2 through CDC20
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
PP2A delays APC/C-dependent degradation of separase-associated but not free securin
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
retrieved
8 April 2019
stated in
Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q12834
determination method
IPI
cell component
biological process

Identifiers

MeSH descriptor ID
D064199
subject named as
Cdc20 Proteins
0 references
 
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