The Mad2 conformational dimer: structure and implications for the spindle assembly checkpoint (Q24300755)

protein homodimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

4

Andrea Musacchio

Andrea

Musacchio

1 reference

26 November 2023

Stefano Santaguida

3

Stefano

Santaguida

1 reference

26 November 2023

Marina Mapelli

1

Marina

Mapelli

1 reference

18022367

26 November 2023

Lucia Massimiliano

series ordinal

2

author given names

Lucia

author last names

Massimiliano

1 reference

18022367

Inducing precocious anaphase in cultured mammalian cells

26 November 2023

language of work or name

English

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publication date

16 November 2007

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published in

Cell

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volume

131

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issue

4

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page(s)

730-43

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cites work

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

How do so few control so many?

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

p31comet blocks Mad2 activation through structural mimicry

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The Mad1/Mad2 complex as a template for Mad2 activation in the spindle assembly checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

In vitro FRAP identifies the minimal requirements for Mad2 kinetochore dynamics.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Molecular gymnastics: serpin structure, folding and misfolding

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The anaphase promoting complex/cyclosome: a machine designed to destroy

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The spindle-assembly checkpoint in space and time

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The Mad2 spindle checkpoint protein has two distinct natively folded states

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Conformation-specific binding of p31(comet) antagonizes the function of Mad2 in the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Determinants of conformational dimerization of Mad2 and its inhibition by p31comet

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Spindle checkpoint requires Mad1-bound and Mad1-free Mad2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The spindle checkpoint of budding yeast depends on a tight complex between the Mad1 and Mad2 proteins

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Identification of a MAD2-binding protein, CMT2, and its role in mitosis

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

A genetic algorithm for the identification of conformationally invariant regions in protein molecules

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Breaking symmetry in protein dimers: designs and functions

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021

The dynamic kinetochore-microtubule interface

1 reference

https://api.crossref.org/works/10.1016%2FJ.CELL.2007.08.049

7 January 2021