CD8 antigen, alpha chain (Q21494041)

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mammalian protein found in Mus musculus
  • T-cell surface glycoprotein CD8 alpha chain
  • T-cell surface glycoprotein Lyt-2
  • Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
  • Cd8a
edit
Language Label Description Also known as
English
CD8 antigen, alpha chain
mammalian protein found in Mus musculus
  • T-cell surface glycoprotein CD8 alpha chain
  • T-cell surface glycoprotein Lyt-2
  • Lyt-2.1 lymphocyte differentiation antigen (AA at 100)
  • Cd8a

Statements

molecular function
cell component
external side of plasma membrane
determination method
IDA
ISO
36 references
retrieved
24 April 2018
stated in
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
ISO
retrieved
24 April 2018
stated in
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
GATA-3 is required for early T lineage progenitor development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin‐2‐deficient colitis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
CDK6 kinase activity is required for thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Accessory protein-like is essential for IL-18-mediated signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Glycosyltransferase function in core 2-type protein O glycosylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
GATA-3 regulates the development and function of invariant NKT cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
STAT5 is required for thymopoiesis in a development stage-specific manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Control of MHC restriction by TCR Valpha CDR1 and CDR2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
CD8 is needed for development of cytotoxic T cells but not helper T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
24 April 2018
stated in
Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P01731&geneProductId=UniProtKB:P01731
determination method
IDA
external side of plasma membrane
determination method
IBA
IDA
ISO
37 references
retrieved
9 May 2019
stated in
FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
ISO
retrieved
9 May 2019
stated in
Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
CD8 is needed for development of cytotoxic T cells but not helper T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin‐2‐deficient colitis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Dissociation of severe lupus-like disease from polyclonal B cell activation and IL 2 deficiency in C3H-lpr/lpr mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Accessory protein-like is essential for IL-18-mediated signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
GATA-3 is required for early T lineage progenitor development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
STAT5 is required for thymopoiesis in a development stage-specific manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Control of MHC restriction by TCR Valpha CDR1 and CDR2
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Glycosyltransferase function in core 2-type protein O glycosylation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
CDK6 kinase activity is required for thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
A novel mutation in CD83 results in the development of a unique population of CD4+ T cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant mice lacking or overexpressing p53, bcl-2, or rag-2 genes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
GATA-3 regulates the development and function of invariant NKT cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Successful elimination of memory-type CD8+ T cell subsets by the administration of anti-Gr-1 monoclonal antibody in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01731
determination method
IBA
biological process

Identifiers

 
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