Inhibitor of nuclear factor kappa-B kinase subunit alpha (Q21495135)

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mouse protein (annotated by UniProtKB/Swiss-Prot Q60680)

NFKBIKA
Conserved helix-loop-helix ubiquitous kinase
IKK1
I-kappa-B kinase 1
Nuclear factor NF-kappa-B inhibitor kinase alpha

Language	Label	Description	Also known as
English	Inhibitor of nuclear factor kappa-B kinase subunit alpha	mouse protein (annotated by UniProtKB/Swiss-Prot Q60680)	NFKBIKA Conserved helix-loop-helix ubiquitous kinase IKK1 I-kappa-B kinase 1 Nuclear factor NF-kappa-B inhibitor kinase alpha

Statements

0 references

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q60680

I-kappa-kinase-beta NEMO binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

molecular function

scaffold protein binding

determination method or standard

1 reference

14 February 2019

SASH1 is a scaffold molecule in endothelial TLR4 signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

protein serine/threonine kinase activity

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

determination method or standard

protein kinase activity

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

protein binding

determination method or standard

12 references

14 February 2019

Telomere-independent Rap1 is an IKK adaptor and regulates NF-kappaB-dependent gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Inhibition of IkappaB kinase by vaccinia virus virulence factor B14

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Signal processing by its coil zipper domain activates IKK gamma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

The RET/PTC3 oncogene activates classical NF-κB by stabilizing NIK

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

An anti-interferon activity shared by paramyxovirus C proteins: inhibition of Toll-like receptor 7/9-dependent alpha interferon induction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

kinase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

nucleotide binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

transferase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

identical protein binding

determination method or standard

1 reference

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

determination method or standard

IkappaB kinase activity

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

cytoplasmic side of plasma membrane

determination method or standard

1 reference

14 February 2019

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

CD40 receptor complex

determination method or standard

1 reference

14 February 2019

HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

biological process

I-kappaB phosphorylation

determination method or standard

1 reference

14 February 2019

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

determination method or standard

mammary gland epithelial cell proliferation

determination method or standard

mammary gland alveolus development

determination method or standard

response to muscle stretch

determination method or standard

1 reference

14 February 2019

Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

morphogenesis of an epithelial sheet

determination method or standard

1 reference

14 February 2019

A dual role for Ikk alpha in tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

phosphorylation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

2 references

odontogenesis of dentin-containing tooth

determination method or standard

1 reference

14 February 2019

A dual role for Ikk alpha in tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

signal transduction

determination method or standard

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

determination method or standard

inflammatory response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

tumor necrosis factor-mediated signaling pathway

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

innate immune response

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q60680&geneProductId=UniProtKB:Q60680

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

positive regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

I-kappaB kinase/NF-kappaB signaling

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

cellular response to reactive oxygen species

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

NIK/NF-kappaB signaling

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

defense response to virus

determination method or standard

1 reference

14 February 2019

A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

cellular response to cadmium ion

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

negative regulation of NF-kappaB transcription factor activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

Rho protein signal transduction

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

response to organic substance

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

response to lipopolysaccharide

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

striated muscle cell differentiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

response to cholecystokinin

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

positive regulation of I-kappaB kinase/NF-kappaB signaling

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

14 February 2019

IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q60680

determination method or standard

Identifiers

UniProt protein ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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