Interleukin 3 (Q21495866)

http://www.ebi.ac.uk/interpro/protein/P01586

four-helical cytokine-like, core

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P01586

1 reference

25 May 2022

1 reference

25 May 2022

growth factor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Stat5 expression is critical for mast cell development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

interleukin-1 receptor binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01586&geneProductId=UniProtKB:P01586

10 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Stat5 expression is critical for mast cell development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

interleukin-3 receptor binding

3 references

2 references

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

positive regulation of protein phosphorylation

biological process

1 reference

14 February 2019

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

1 reference

14 February 2019

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

interleukin-3-mediated signaling pathway

IGI

1 reference

14 February 2019

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

cytokine-mediated signaling pathway

1 reference

14 February 2019

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

negative regulation of mast cell apoptotic process

1 reference

14 February 2019

Stat5 expression is critical for mast cell development and survival

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

regulation of protein dephosphorylation

1 reference

14 February 2019

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode

monocyte differentiation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

regulation of glycolytic process

IGI

1 reference

14 February 2019

The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

positive regulation of myeloid leukocyte differentiation

IGI

2 references

14 February 2019

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

extrinsic apoptotic signaling pathway in absence of ligand

IEA

6 references

14 February 2019

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

The role of Asp-462 in regulating Akt activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

BAD is a pro-survival factor prior to activation of its pro-apoptotic function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

regulation of gene expression

1 reference

14 February 2019

Mice defective in two apoptosis pathways in the myeloid lineage develop acute myeloblastic leukemia

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

activation of Janus kinase activity

1 reference

14 February 2019

Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

negative regulation of autophagy

1 reference

14 February 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

myeloid cell apoptotic process

1 reference

14 February 2019

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P01586&geneProductId=UniProtKB:P01586

regulation of signaling receptor activity

IBA

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

positive regulation of cell population proliferation

IEA

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Interleukin-12 enhances interleukin-3 dependent multilineage hematopoietic colony formation stimulated by interleukin-11 or steel factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

14 February 2019

Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P01586