Tight junction protein 1 (Q21496047)

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mammalian protein found in Mus musculus
  • zona occludens protein 1
  • Tjp1
  • tight junction protein ZO-1
  • zonula occludens protein 1
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Language Label Description Also known as
English
Tight junction protein 1
mammalian protein found in Mus musculus
  • zona occludens protein 1
  • Tjp1
  • tight junction protein ZO-1
  • zonula occludens protein 1

Statements

molecular function
protein binding
determination method
IPI
8 references
retrieved
14 February 2019
stated in
Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Bves modulates epithelial integrity through an interaction at the tight junction
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Vinculin directly binds zonula occludens-1 and is essential for stabilizing connexin-43-containing gap junctions in cardiac myocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
retrieved
14 February 2019
stated in
Expression of zonula occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IPI
cell component
cell-cell junction
determination method
IDA
7 references
retrieved
14 February 2019
stated in
Progressive Hearing Loss in Mice Carrying a Mutation in Usp53.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Nectins localize Willin to cell-cell junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Basolateral Mg2+ extrusion via CNNM4 mediates transcellular Mg2+ transport across epithelia: a mouse model
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
bicellular tight junction
determination method
IDA
IEA
ISO
33 references
retrieved
14 February 2019
stated in
Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Mutagenesis of the epithelial polarity gene, discs large 1, perturbs nephrogenesis in the developing mouse kidney
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Normal establishment of epithelial tight junctions in mice and cultured cells lacking expression of ZO-3, a tight-junction MAGUK protein
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Cdx2 regulates endo-lysosomal function and epithelial cell polarity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Asymmetric distribution of PAR proteins in the mouse embryo begins at the 8-cell stage during compaction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Expression and distribution of ZO‐3, a tight junction MAGUK protein, in mouse tissues
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Distinct subdomain organization and molecular composition of a tight junction with adherens junction features
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Tricellulin deficiency affects tight junction architecture and cochlear hair cells.
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Identification of PKCzetaII: an endogenous inhibitor of cell polarity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Tyrosinase: a developmentally specific major determinant of peripheral dopamine
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
plasma membrane
determination method
IDA
IEA
ISO
10 references
retrieved
14 February 2019
stated in
Identification and subcellular localization of a new cystinosin isoform
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Identification and subcellular localization of a new cystinosin isoform
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
CTRP5 is a membrane-associated and secretory protein in the RPE and ciliary body and the S163R mutation of CTRP5 impairs its secretion
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Dynamic assembly of tight junction-associated proteins ZO-1, ZO-2, ZO-3 and occludin during mouse tooth development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Regulation of connexin43 protein complexes by intracellular acidification
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
cell junction
determination method
IDA
IEA
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39447
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IEA
retrieved
14 February 2019
stated in
Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
A coronary artery disease-associated gene product, JCAD/KIAA1462, is a novel component of endothelial cell-cell junctions
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
retrieved
14 February 2019
stated in
Tight function zonula occludens-3 regulates cyclin D1-dependent cell proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39447
determination method
IDA
biological process

Identifiers

RefSeq protein ID
 
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