MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway (Q28506694)

24 January 2017

title

MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway (English)

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Microcephaly, primary autosomal recessive 1

24 January 2017

main subject

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GOA release 2020-03-11

Cadherin 2

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GOA release 2020-03-11

Tight junction protein 1

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GOA release 2020-03-11

Zhongwei Zhou

2

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Pierre-Olivier Frappart

object named as

Pierre-Olivier Frappart

5

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author name string

Ralph Gruber

1

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24 January 2017

Mikhail Sukchev

3

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24 January 2017

Tjard Joerss

4

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24 January 2017

Zhao-Qi Wang

6

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24 January 2017

language of work or name

English

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publication date

25 September 2011

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24 January 2017

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24 January 2017

volume

13

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24 January 2017

issue

11

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24 January 2017

page(s)

1325–1334

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Molecular genetic determinants of human brain size

24 January 2017

cites work

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Microcephalin, a Gene Regulating Brain Size, Continues to Evolve Adaptively in Humans

21 January 2018

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Molecular evolution of microcephalin, a gene determining human brain size

21 January 2018

1 reference

Autosomal recessive primary microcephaly (MCPH): a review of clinical, molecular, and evolutionary findings

21 January 2018

1 reference

Primary microcephaly: do all roads lead to Rome?

21 January 2018

1 reference

WDR62 is associated with the spindle pole and is mutated in human microcephaly

21 January 2018

1 reference

Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.

21 January 2018

1 reference

Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture

21 January 2018

1 reference

Premature chromosome condensation in humans associated with microcephaly and mental retardation: a novel autosomal recessive condition

21 January 2018

1 reference

Mutations in microcephalin cause aberrant regulation of chromosome condensation.

21 January 2018

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Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair.

21 January 2018

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Misregulated Chromosome Condensation in MCPH1 Primary Microcephaly is Mediated by Condensin II

21 January 2018

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Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization.

21 January 2018

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BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly

21 January 2018

1 reference

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

21 January 2018

1 reference

Regulation of mitotic entry by microcephalin and its overlap with ATR signalling

21 January 2018

1 reference

Microcephalin Is a DNA Damage Response Protein Involved in Regulation of CHK1 and BRCA1

21 January 2018

1 reference

BRIT1/MCPH1 links chromatin remodelling to DNA damage response.

21 January 2018

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MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis

21 January 2018

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DNA repair deficiency and neurological disease

21 January 2018

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Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling

21 January 2018

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Cytoskeletal genes regulating brain size

21 January 2018

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Symmetric versus asymmetric cell division during neurogenesis in the developing vertebrate central nervous system

21 January 2018

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Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion

21 January 2018

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Identification of microcephalin, a protein implicated in determining the size of the human brain

21 January 2018

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BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice

21 January 2018

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Mechanisms of asymmetric stem cell division

21 January 2018

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Neurogenesis and asymmetric cell division

21 January 2018

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Making bigger brains-the evolution of neural-progenitor-cell division.

21 January 2018

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Spindle regulation in neural precursors of flies and mammals

21 January 2018

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Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells

21 January 2018

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Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

21 January 2018

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The centrosome in neuronal development

21 January 2018

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Centrosome control of the cell cycle

21 January 2018

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Microcephalin and pericentrin regulate mitotic entry via centrosome-associated Chk1

21 January 2018

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Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase

21 January 2018

1 reference

Centrioles, centrosomes, and cilia in health and disease

21 January 2018

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Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.

21 January 2018

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Oncogenes and tumour suppressors take on centrosomes

21 January 2018

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Chk1 is required for spindle checkpoint function.

21 January 2018

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Chk1-dependent regulation of Cdc25B functions to coordinate mitotic events

21 January 2018

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Evolution of the brain and intelligence

21 January 2018

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Mitotic catastrophe: a mechanism for avoiding genomic instability.

21 January 2018

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Cell death by mitotic catastrophe: a molecular definition

21 January 2018

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Mutations in the pericentrin (PCNT) gene cause primordial dwarfism

21 January 2018

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Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division.

21 January 2018

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Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors

21 January 2018

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Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells

21 January 2018

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Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline

21 January 2018

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The drosophila protein asp is involved in microtubule organization during spindle formation and cytokinesis

21 January 2018

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Maintaining the proper connection between the centrioles and the pericentriolar matrix requires Drosophila centrosomin

21 January 2018

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21 January 2018

Flies without centrioles

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Microcephalin coordinates mitosis in the syncytial Drosophila embryo

21 January 2018

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Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex

21 January 2018

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Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function

21 January 2018

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Mechanisms of asymmetric cell division: flies and worms pave the way.

21 January 2018

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Cytokinesis of neuroepithelial cells can divide their basal process before anaphase

21 January 2018

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PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130

21 January 2018

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Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population.

21 January 2018

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In vivo electroporation in the embryonic mouse central nervous system

21 January 2018

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An essential function for NBS1 in the prevention of ataxia and cerebellar defects

21 January 2018

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Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress

21 January 2018

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Neural stem and progenitor cells shorten S-phase on commitment to neuron production

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21947081

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The multiple checkpoint functions of CHK1 and CHK2 in maintenance of genome stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/21947081