Rho guanine nucleotide exchange factor (GEF7) (Q21496092)

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mammalian protein found in Mus musculus

rho guanine nucleotide exchange factor 7
p85SPR
Pak3 binding protein
Arhgef7
beta-Pix
PAK-interacting exchange factor beta

Language	Label	Description	Also known as
English	Rho guanine nucleotide exchange factor (GEF7)	mammalian protein found in Mus musculus	rho guanine nucleotide exchange factor 7 p85SPR Pak3 binding protein Arhgef7 beta-Pix PAK-interacting exchange factor beta

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Dbl homology (DH) domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

CH domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rho guanine nucleotide exchange factor, coiled-coil domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Calponin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rho guanine nucleotide exchange factor 7, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Dbl homology (DH) domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Guanine-nucleotide dissociation stimulator, CDC24, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

guanyl-nucleotide exchange factor activity

determination method

5 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

protein binding

determination method

9 references

16 September 2017

A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Proteomics analysis of immuno-precipitated synaptic protein complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Affixin activates Rac1 via betaPIX in C2C12 myoblast

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

protein kinase binding

determination method

3 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

determination method

1 reference

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

cell projection

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

determination method

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

plasma membrane

determination method

1 reference

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

storage vacuole

determination method

1 reference

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

biological process

intracellular signal transduction

determination method

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

nervous system development

determination method

1 reference

16 September 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

positive regulation of GTPase activity

determination method

4 references

16 September 2017

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

16 September 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

positive regulation of growth hormone secretion

determination method

1 reference

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

hematopoietic progenitor cell differentiation

determination method

1 reference

16 September 2017

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

positive regulation of apoptotic process

determination method

positive regulation of protein binding

determination method

1 reference

16 September 2017

Cool-1/βPIX functions as a guanine nucleotide exchange factor in the cycling of Cdc42 to regulate insulin secretion

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

regulation of Rho protein signal transduction

determination method

1 reference

16 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

lamellipodium assembly

determination method

1 reference

16 September 2017

Affixin activates Rac1 via betaPIX in C2C12 myoblast

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9ES28&geneProductId=UniProtKB:Q9ES28

determination method

Calponin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Dbl homology (DH) domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Guanine-nucleotide dissociation stimulator, CDC24, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Rho guanine nucleotide exchange factor, coiled-coil domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Rho guanine nucleotide exchange factor 7, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9ES28

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000096538

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000096538

ENSMUSP00000106534

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106534

ENSMUSP00000074399

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000074399

ENSMUSP00000106529

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000106529

ENSMUSP00000147641

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000147641

ENSMUSP00000148109

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148109

ENSMUSP00000148111

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000148111

ENSMUSP00000159352

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000159352

PDB structure ID

1 reference

UniProt protein ID

10 August 2016

language of work or name

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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