ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2 (Q24305448)

Cell division cycle 42

1 reference

Rho guanine nucleotide exchange factor 7

1 reference

GTP metabolic process

1 reference

Rho guanine nucleotide exchange factor (GEF7)

1 reference

Cell division cycle 42

1 reference

Leucine-rich repeat kinase 2

1 reference

Christian Johannes Gloeckner

0 references

7

0 references

2

0 references

Claudia Schulte

object named as

Claudia Schulte

5

0 references

Olaf Riess

6

object named as

Olaf Riess

0 references

author name string

Karina Haebig

1

0 references

Marta Garcia Miralles

3

0 references

Frank Gillardon

4

0 references

Saskia Biskup

8

0 references

Michael Bonin

Creative Commons Attribution 4.0 International

9

0 references

language of work or name

English

0 references

publication date

2010

0 references

published in

PLOS One

0 references

volume

5

0 references

issue

10

0 references

page(s)

e13762

0 references

copyright license

start time

29 October 2010

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

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Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

19 March 2017

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The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

19 March 2017

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The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

19 March 2017

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Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

19 March 2017

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A novel tandem affinity purification strategy for the efficient isolation and characterisation of native protein complexes

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

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GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

19 March 2017

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

19 March 2017

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

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Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration

19 March 2017

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

19 March 2017

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Structure of the Roc–COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase

19 March 2017

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

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Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease

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27 September 2017

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Identification of the autophosphorylation sites of LRRK2.

27 September 2017

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Interaction of elongation factor 1-alpha with leucine-rich repeat kinase 2 impairs kinase activity and microtubule bundling in vitro

27 September 2017

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Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability--a point of convergence in parkinsonian neurodegeneration?

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The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules

27 September 2017

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RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player

27 September 2017

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The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

27 September 2017

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Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

27 September 2017

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Regulation of the Cool/Pix proteins: key binding partners of the Cdc42/Rac targets, the p21-activated kinases

27 September 2017

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Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells

27 September 2017

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Intramolecular activation mechanism of the Dictyostelium LRRK2 homolog Roco protein GbpC.

27 September 2017

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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

30 May 2018

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Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

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Evaluation of the impact of some experimental procedures on different phosphopeptide enrichment techniques

21 January 2018

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A chromosome 4p haplotype segregating with Parkinson's disease and postural tremor

21 January 2018

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21 January 2018

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https://pubmed.ncbi.nlm.nih.gov/21048939

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21048939

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Strep/FLAG tandem affinity purification (SF-TAP) to study protein interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21048939