Lysine (K)-specific demethylase 6A (Q21497906)

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mammalian protein found in Mus musculus

Kdm6a
[histone H3]-trimethyl-L-lysine(27) demethylase 6A
histone demethylase UTX
ubiquitously transcribed X chromosome tetratricopeptide repeat protein
lysine-specific demethylase 6A
ubiquitously transcribed TPR protein on the X chromosome
ubiquitously transcribed tetratricopeptide repeat gene, X chromosome

Language	Label	Description	Also known as
English	Lysine (K)-specific demethylase 6A	mammalian protein found in Mus musculus	Kdm6a [histone H3]-trimethyl-L-lysine(27) demethylase 6A histone demethylase UTX ubiquitously transcribed X chromosome tetratricopeptide repeat protein lysine-specific demethylase 6A ubiquitously transcribed TPR protein on the X chromosome ubiquitously transcribed tetratricopeptide repeat gene, X chromosome

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Tetratricopeptide-like helical domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70546

JmjC domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat-containing domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Tetratricopeptide repeat family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

dioxygenase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

1 reference

24 April 2018

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

protein binding

determination method or standard

5 references

14 February 2019

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

identical protein binding

determination method or standard

1 reference

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

oxidoreductase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

chromatin DNA binding

determination method or standard

1 reference

24 April 2018

Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

chromatin binding

determination method or standard

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

sequence-specific DNA binding

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

histone H3-tri/di-methyl-lysine-27 demethylase activity

determination method or standard

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

determination method or standard

4 references

24 April 2018

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

24 April 2018

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=O70546&geneProductId=UniProtKB:O70546

determination method or standard

histone methyltransferase complex

determination method or standard

3 references

14 February 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

determination method or standard

5 references

14 February 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

biological process

respiratory system process

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

multicellular organism growth

determination method or standard

1 reference

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

embryonic organ development

determination method or standard

1 reference

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

somite rostral/caudal axis specification

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

heart morphogenesis

determination method or standard

1 reference

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

in utero embryonic development

determination method or standard

heart development

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

neural tube closure

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

positive regulation of gene expression

determination method or standard

1 reference

14 February 2019

Female bias in Rhox6 and 9 regulation by the histone demethylase KDM6A

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

notochord morphogenesis

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

neural tube development

determination method or standard

1 reference

14 February 2019

UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

mesodermal cell differentiation

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

canonical Wnt signaling pathway

determination method or standard

1 reference

14 February 2019

UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

chromatin remodeling

determination method or standard

1 reference

14 February 2019

Jmjd3 and UTX play a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

chromatin organization

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O70546

determination method or standard

tetratricopeptide repeat

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70546

Tetratricopeptide repeat-containing domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70546

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O70546

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

1 reference

10 April 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000045862

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000045862

ENSMUSP00000061539

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000061539

ENSMUSP00000153267

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153267

ENSMUSP00000153609

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153609

ENSMUSP00000153215

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153215

ENSMUSP00000153167

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000153167

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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