Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases (Q21562402)

April 2022 Public Data File from Crossref

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cites work

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Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis

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Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

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Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB

19 March 2017

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19 March 2017

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Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

19 March 2017

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Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis

19 March 2017

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The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance

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Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis

19 March 2017

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

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Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG

7 April 2017

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

12 September 2017

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Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity

12 September 2017

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A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

12 September 2017

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Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy

12 September 2017

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Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

12 September 2017

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27 September 2017

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Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

27 September 2017

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Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

30 May 2018

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Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

29 November 2018

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Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum

29 November 2018

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Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile

29 November 2018

1 reference

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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19609444

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0006306

1 reference

3765744

ADS bibcode

2009PLoSO...4.6306B

0 references

3765744

1 reference

1 reference

1 reference