Phospholipase C, gamma 2 (Q21981083)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Mus musculus

PLC-gamma-2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Plcg2
Phospholipase C-gamma-2
phosphoinositide phospholipase C-gamma-2

Language	Label	Description	Also known as
English	Phospholipase C, gamma 2	mammalian protein found in Mus musculus	PLC-gamma-2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 Plcg2 Phospholipase C-gamma-2 phosphoinositide phospholipase C-gamma-2

Statements

1 reference

25 May 2022

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

PH-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

pleckstrin homology domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLC-gamma, C-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PLC-gamma, N-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

signal transducer activity

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

protein binding

determination method

5 references

24 April 2018

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

phosphoric diester hydrolase activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

phospholipase C activity

determination method

1 reference

14 February 2019

Absence of erythrogenesis and vasculogenesis in Plcg1-deficient mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

hydrolase activity

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

phosphatidylinositol phospholipase C activity

determination method

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

phosphatidylinositol phospholipase C activity

determination method

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

protein binding

determination method

6 references

14 February 2019

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Erythropoietin receptor Y479 couples to ERK1/2 activation via recruitment of phospholipase Cgamma

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

plasma membrane

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

plasma membrane

determination method

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

biological process

B cell receptor signaling pathway

determination method

1 reference

14 February 2019

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

release of sequestered calcium ion into cytosol

determination method

3 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

intracellular signal transduction

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

inositol trisphosphate biosynthetic process

determination method

1 reference

11 October 2018

Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIH5&geneProductId=UniProtKB:Q8CIH5

determination method

positive regulation of receptor internalization

determination method

1 reference

14 February 2019

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

lipid metabolism

determination method

2 references

lipid catabolic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

follicular B cell differentiation

determination method

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

response to lipopolysaccharide

determination method

1 reference

14 February 2019

Lipopolysaccharide-induced biphasic inositol 1,4,5-trisphosphate response and tyrosine phosphorylation of 140-kilodalton protein in mouse peritoneal macrophages

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

phospholipid catabolic process

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

regulation of gene expression

determination method

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

phosphatidylinositol biosynthetic process

determination method

3 references

negative regulation of programmed cell death

determination method

1 reference

14 February 2019

Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

B cell differentiation

determination method

1 reference

14 February 2019

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

T cell receptor signaling pathway

determination method

1 reference

14 February 2019

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

activation of store-operated calcium channel activity

determination method

1 reference

14 February 2019

Distinct calcium channels regulate responses of primary B lymphocytes to B cell receptor engagement and mechanical stimuli

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

positive regulation of type I interferon production

determination method

1 reference

14 February 2019

CD14 controls the LPS-induced endocytosis of Toll-like receptor 4

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

signal transduction

determination method

2 references

positive regulation of cytosolic calcium ion concentration

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

response to magnesium ion

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

response to ATP

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

release of sequestered calcium ion into cytosol

determination method

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Cutting edge: essential role of phospholipase C-gamma 2 in B cell development and function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

inositol trisphosphate biosynthetic process

determination method

phosphatidylinositol-mediated signaling

determination method

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIH5

determination method

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

pleckstrin homology domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

PLC-gamma, N-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

PLC-gamma, C-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIH5

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000079991

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000079991

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21981083&oldid=2023200056"