TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk (Q28854385)

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Language	Label	Description	Also known as
English	TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk	scientific journal article

Statements

scholarly article

1 reference

PubMed publication ID

28 February 2017

TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk (English)

1 reference

PubMed publication ID

28 February 2017

Spleen tyrosine kinase

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GOA release 2020-03-11

Ubiquitin associated and SH3 domain containing, B

1 reference

GOA release 2020-03-11

Glycoprotein 6 (platelet)

1 reference

GOA release 2020-03-11

Ubiquitin associated and SH3 domain containing, A

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GOA release 2020-03-11

Phospholipase C, gamma 2

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GOA release 2020-03-11

Phospholipase C, gamma 1

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GOA release 2020-03-11

Lymphocyte cytosolic protein 2

1 reference

GOA release 2020-03-11

author name string

Kevin Reppschläger

1

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PubMed publication ID

28 February 2017

Jeanne Gosselin

2

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PubMed publication ID

28 February 2017

Carol A. Dangelmaier

3

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PubMed publication ID

28 February 2017

Dafydd H. Thomas

4

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PubMed publication ID

28 February 2017

Nick Carpino

5

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PubMed publication ID

28 February 2017

Steven E. McKenzie

6

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PubMed publication ID

28 February 2017

Satya P. Kunapuli

7

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PubMed publication ID

28 February 2017

Alexander Y. Tsygankov

8

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PubMed publication ID

28 February 2017

language of work or name

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publication date

21 October 2016

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PubMed publication ID

28 February 2017

Journal of Biological Chemistry

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PubMed publication ID

28 February 2017

291

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PubMed publication ID

28 February 2017

43

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PubMed publication ID

28 February 2017

22427–22441

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PubMed publication ID

28 February 2017

Platelet signaling: a complex interplay between inhibitory and activatory networks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

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Enhanced response of T cells from murine gammaherpesvirus 68-infected mice lacking the suppressor of T cell receptor signaling molecules Sts-1 and Sts-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Insights into the suppressor of T-cell receptor (TCR) signaling-1 (Sts-1)-mediated regulation of TCR signaling through the use of novel substrate-trapping Sts-1 phosphatase variants

1 reference

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Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker

1 reference

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16 March 2017

Structural and biophysical characterization of the Syk activation switch

1 reference

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16 March 2017

TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Molecular mechanism of the Syk activation switch

1 reference

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The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development

1 reference

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16 March 2017

A Phosphatase Activity of Sts-1 Contributes to the Suppression of TCR Signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Phosphorylation of Tyr342 in the linker region of Syk is critical for Fc epsilon RI signaling in mast cells

1 reference

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16 March 2017

Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein

1 reference

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16 March 2017

Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway

1 reference

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16 March 2017

Interaction of linker for activation of T cells with multiple adapter proteins in platelets activated by the glycoprotein VI-selective ligand, convulxin

1 reference

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16 March 2017

Phosphorylation of Syk activation loop tyrosines is essential for Syk function. An in vivo study using a specific anti-Syk activation loop phosphotyrosine antibody

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Evidence for a role for tyrosine phosphorylation of phospholipase C gamma 2 in collagen-induced platelet cytosolic calcium mobilization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

16 March 2017

Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Anti-miR-148a regulates platelet FcγRIIA signaling and decreases thrombosis in vivo in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

The Phosphatases STS1 and STS2 Regulate Hematopoietic Stem and Progenitor Cell Fitness.

1 reference

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3 June 2018

Members of the novel UBASH3/STS/TULA family of cellular regulators suppress T-cell-driven inflammatory responses in vivo

1 reference

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3 June 2018

TULA-family proteins: a new class of cellular regulators

1 reference

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3 June 2018

Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Complex phosphorylation dynamics control the composition of the Syk interactome in B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Sts-2 is a phosphatase that negatively regulates zeta-associated protein (ZAP)-70 and T cell receptor signaling pathways

1 reference

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3 June 2018

Determination of the Substrate Specificity of Protein-tyrosine Phosphatase TULA-2 and Identification of Syk as a TULA-2 Substrate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Tyrosines in the carboxyl terminus regulate Syk kinase activity and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

TULA-family proteins: an odd couple

1 reference

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Tyr130 phosphorylation triggers Syk release from antigen receptor by long-distance conformational uncoupling

1 reference

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Multidomain STS/TULA proteins are novel cellular regulators

1 reference

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3 June 2018

TULA proteins regulate activity of the protein tyrosine kinase Syk.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.

1 reference

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Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases

1 reference

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T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis

1 reference

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3 June 2018

Protein tyrosine phosphatase function: the substrate perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Crystallization and initial crystal characterization of the C-terminal phosphoglycerate mutase homology domain of Sts-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

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Non-receptor protein tyrosine kinases

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Collagen receptor signaling in platelets and megakaryocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Evidence for the involvement of p59fyn and p53/56lyn in collagen receptor signalling in human platelets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Activation-dependent tyrosine phosphorylation of Fyn-associated proteins in T lymphocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Diminished tyrosine protein kinase activity in T cells unresponsive to TCR stimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Syk interacts with tyrosine-phosphorylated proteins in human platelets activated by collagen and cross-linking of the Fc gamma-IIA receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

3 June 2018

Collagen receptor signalling in platelets: extending the role of the ITAM.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M116.743732

21 January 2018

Genetic and pharmacological analyses of involvement of Src-family, Syk and Btk tyrosine kinases in platelet shape change. Src-kinases mediate integrin alphaIIb beta3 inside-out signalling during shape change.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5077183

26 November 2018

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/27609517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Tyr518 and Tyr519 in the regulation of catalytic activity and substrate phosphorylation by Syk protein-tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/27609517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/27609517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Collagen stimulates tyrosine phosphorylation of phospholipase C-γ2 but not phospholipase C-γ1 in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/27609517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/27609517

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M116.743732

1 reference

PubMed publication ID

28 February 2017

PMC publication ID

0 references

PubMed publication ID

1 reference

PubMed publication ID

28 February 2017

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