Ankyrin 2, brain (Q21981195)

http://www.ebi.ac.uk/interpro/protein/Q8C8R3

Ankyrin repeat-containing domain superfamily

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8C8R3

membrane protein

1 reference

inferred from GOA cell component → membrane

Ankyrin repeat-containing domain, protein family

1 reference

Death domain, protein family

1 reference

ZU5 domain, protein family

1 reference

Ankyrin repeat, protein family

1 reference

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

potassium channel regulator activity

IPI

1 reference

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

7 references

14 February 2019

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

6 references

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Obscurin targets ankyrin-B and protein phosphatase 2A to the cardiac M-line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

postsynaptic membrane

1 reference

14 February 2019

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

3 references

16 July 2018

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

16 July 2018

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

integral component of plasma membrane

1 reference

14 February 2019

Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

intracellular anatomical structure

1 reference

16 July 2018

Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

4 references

10 September 2018

Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

10 September 2018

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

10 September 2018

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

10 September 2018

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

apical plasma membrane

1 reference

10 September 2018

perinuclear region of cytoplasm

1 reference

14 February 2019

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

2 references

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

4 references

14 February 2019

Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of apoptotic process

biological process

1 reference

1 January 2018

Comparative analysis of apoptosis and inflammation genes of mice and humans

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8C8R3&geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of cardiac muscle contraction by calcium ion signaling

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

cardiac muscle contraction

1 reference

14 February 2019

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of protein stability

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

IC

3 references

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

SA node cell action potential

IC

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

Targeting and stability of Na/Ca exchanger 1 in cardiomyocytes requires direct interaction with the membrane adaptor ankyrin-B

protein stabilization

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

cellular calcium ion homeostasis

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

positive regulation of calcium ion transmembrane transporter activity

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

regulation of heart rate

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of cardiac muscle cell contraction

1 reference

14 February 2019

Defining the cellular phenotype of "ankyrin-B syndrome" variants: human ANK2 variants associated with clinical phenotypes display a spectrum of activities in cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

protein localization to T-tubule

1 reference

14 February 2019

Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

positive regulation of gene expression

regulation of cation channel activity

1 reference

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

protein localization to cell surface

1 reference

14 February 2019

Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

atrial cardiac muscle cell action potential

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

SA node cell to atrial cardiac muscle cell communication

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

atrial cardiac muscle cell to AV node cell communication

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of SA node cell action potential

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of cardiac muscle contraction

1 reference

14 February 2019

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

protein localization to endoplasmic reticulum

regulation of heart rate by cardiac conduction

3 references

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

A cardiac arrhythmia syndrome caused by loss of ankyrin-B function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of AV node cell action potential

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of calcium ion transmembrane transporter activity

1 reference

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

regulation of atrial cardiac muscle cell action potential

1 reference

14 February 2019

Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

positive regulation of calcium ion transport

1 reference

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

protein localization to plasma membrane

7 references

14 February 2019

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

Ankyrin-B regulates Kir6.2 membrane expression and function in heart

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

14 February 2019

EH domain proteins regulate cardiac membrane protein targeting

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8C8R3