Sine oculis-related homeobox 1 (Q21981883)

Homeobox protein SIX1

1 reference

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox protein SIX1, N-terminal SD domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

sequence-specific DNA binding

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

DNA-binding transcription factor activity

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

DNA-binding transcription activator activity, RNA polymerase II-specific

4 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

6 references

9 May 2019

Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Ski regulates muscle terminal differentiation by transcriptional activation of Myog in a complex with Six1 and Eya3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

SIX1 mutations cause branchio-oto-renal syndrome by disruption of EYA1-SIX1-DNA complexes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

transcription cis-regulatory region binding

IPI

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

DNA-binding transcription activator activity, RNA polymerase II-specific

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

DNA-binding transcription activator activity, RNA polymerase II-specific

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

DNA-binding transcription factor activity, RNA polymerase II-specific

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

24 April 2018

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

24 April 2018

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

transcription regulator complex

1 reference

24 April 2018

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

negative regulation of neuron apoptotic process

biological process

1 reference

9 May 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of neuron differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

animal organ development

1 reference

14 February 2019

1 reference

9 May 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

embryonic skeletal system morphogenesis

1 reference

9 May 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

renal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

mesonephric tubule formation

1 reference

9 May 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

1 January 2018

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

epithelial cell differentiation

1 reference

9 May 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

olfactory placode formation

1 reference

9 May 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of skeletal muscle cell differentiation

1 reference

9 May 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

Development of gustatory papillae in the absence of Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

Six1 is required for the early organogenesis of mammalian kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

Development and differentiation of the ureteric bud into the ureter in the absence of a kidney collecting system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

anatomical structure development

1 reference

24 April 2018

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

ureter smooth muscle cell differentiation

1 reference

9 May 2019

SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

neuron fate specification

1 reference

9 May 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

skeletal system morphogenesis

1 reference

9 May 2019

The role of Six1 in mammalian auditory system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

outflow tract morphogenesis

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

trigeminal ganglion development

1 reference

9 May 2019

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

negative regulation of apoptotic process

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

sensory perception of sound

1 reference

9 May 2019

The role of Six1 in mammalian auditory system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of branch elongation involved in ureteric bud branching

1 reference

9 May 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

transcription, DNA-templated

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

fungiform papilla morphogenesis

1 reference

9 May 2019

Development of gustatory papillae in the absence of Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

Six1 and Six4 promote survival of sensory neurons during early trigeminal gangliogenesis

generation of neurons

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

otic vesicle development

regulation of protein localization

1 reference

9 May 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

multicellular organism development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of transcription, DNA-templated

4 references

9 May 2019

Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Six1 and Six4 gene expression is necessary to activate the fast-type muscle gene program in the mouse primary myotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

branching involved in ureteric bud morphogenesis

1 reference

9 May 2019

Six1 is required for the early organogenesis of mammalian kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

thyroid gland development

1 reference

9 May 2019

Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

inner ear morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

The role of Six1 in mammalian auditory system development

cochlea morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of ureteric bud formation

1 reference

9 May 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of mesenchymal cell proliferation involved in ureter development

1 reference

9 May 2019

SIX1 acts synergistically with TBX18 in mediating ureteral smooth muscle formation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

The role of Six1 in mammalian auditory system development

middle ear morphogenesis

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of synaptic assembly at neuromuscular junction

1 reference

9 May 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of gene expression

1 reference

9 May 2019

Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

embryonic cranial skeleton morphogenesis

1 reference

9 May 2019

Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

Catweasel mice: a novel role for Six1 in sensory patch development and a model for branchio-oto-renal syndrome

inner ear development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of secondary heart field cardioblast proliferation

1 reference

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

negative regulation of branching involved in ureteric bud morphogenesis

1 reference

1 January 2018

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of epithelial cell proliferation

1 reference

9 May 2019

Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of skeletal muscle satellite cell proliferation

1 reference

9 May 2019

Six family genes control the proliferation and differentiation of muscle satellite cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

skeletal muscle tissue development

metanephric mesenchyme development

1 reference

9 May 2019

Six1 and Six4 are essential for Gdnf expression in the metanephric mesenchyme and ureteric bud formation, while Six1 deficiency alone causes mesonephric-tubule defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

facial nerve morphogenesis

1 reference

9 May 2019

The role of Six1 in mammalian auditory system development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of transcription by RNA polymerase II

5 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Slc12a2 is a direct target of two closely related homeobox proteins, Six1 and Six4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

transcription by RNA polymerase II

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q62231&geneProductId=UniProtKB:Q62231

skeletal muscle tissue development

3 references

9 May 2019

Six proteins regulate the activation of Myf5 expression in embryonic mouse limbs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Six1 and Six4 homeoproteins are required for Pax3 and Mrf expression during myogenesis in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

negative regulation of transcription, DNA-templated

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

regulation of skeletal muscle cell proliferation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

skeletal muscle fiber development

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q62231

positive regulation of branching involved in ureteric bud morphogenesis

1 reference

Homeobox, conserved site

1 reference

Homeobox protein SIX1, N-terminal SD domain

1 reference