Rous sarcoma oncogene (Q21984733)

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mammalian protein found in Mus musculus
  • proto-oncogene c-Src
  • p60-Src
  • neuronal proto-oncogene tyrosine-protein kinase Src
  • Src
  • pp60c-src
  • proto-oncogene tyrosine-protein kinase Src
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Language Label Description Also known as
English
Rous sarcoma oncogene
mammalian protein found in Mus musculus
  • proto-oncogene c-Src
  • p60-Src
  • neuronal proto-oncogene tyrosine-protein kinase Src
  • Src
  • pp60c-src
  • proto-oncogene tyrosine-protein kinase Src

Statements

molecular function
protein binding
determination method
IPI
27 references
retrieved
9 May 2019
stated in
Src kinase activity is essential for osteoclast function
GOA
curator
UniProt
UniProt protein ID
P05480
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Dishevelled-2 docks and activates Src in a Wnt-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
A caveolin-3 mutant that causes limb girdle muscular dystrophy type 1C disrupts Src localization and activity and induces apoptosis in skeletal myotubes
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Palmitoylation-dependent endosomal localization of AATYK1A and its interaction with Src
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Deficiency of a beta-arrestin-2 signal complex contributes to insulin resistance.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Identification of profilin and src homology 3 domains as binding partners for Drosophila enabled
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Linker length dependent binding of a focal adhesion kinase derived peptide to the Src SH3-SH2 domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
A proteomics strategy for the enrichment of receptor-associated complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Src kinase activation by direct interaction with the integrin β cytoplasmic domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
PSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Dramatic inhibition of osteoclast sealing ring formation and bone resorption in vitro by a WASP-peptide containing pTyr294 amino acid
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Mobility of TOAC spin-labelled peptides binding to the Src SH3 domain studied by paramagnetic NMR
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
retrieved
9 May 2019
stated in
Molecular mapping of tyrosine-phosphorylated proteins in focal adhesions using fluorescence resonance energy transfer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IPI
protein kinase activity
determination method
IMP
IEA
ISO
IDA
8 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
ISO
retrieved
9 May 2019
stated in
Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IEA
retrieved
9 May 2019
stated in
Dishevelled-2 docks and activates Src in a Wnt-dependent manner
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IDA
retrieved
9 May 2019
stated in
Src and Pyk2 mediate G-protein-coupled receptor activation of epidermal growth factor receptor (EGFR) but are not required for coupling to the mitogen-activated protein (MAP) kinase signaling cascade
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IDA
retrieved
9 May 2019
stated in
Focal Adhesion Kinase-mediated Phosphorylation of Beclin1 Protein Suppresses Cardiomyocyte Autophagy and Initiates Hypertrophic Growth
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IDA
retrieved
9 May 2019
stated in
A reactive oxygen species-mediated, self-perpetuating loop persistently activates platelet-derived growth factor receptor α
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IDA
protein tyrosine kinase activity
determination method
EXP
IEA
IMP
ISO
TAS
8 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
ISO
retrieved
9 May 2019
stated in
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IMP
retrieved
9 May 2019
stated in
Src-induced phosphorylation of caveolin-2 on tyrosine 19. Phospho-caveolin-2 (Tyr(P)19) is localized near focal adhesions, remains associated with lipid rafts/caveolae, but no longer forms a high molecular mass hetero-oligomer with caveolin-1
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P05480
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
IEA
retrieved
9 May 2019
stated in
A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05480
determination method
EXP
cell component
biological process

Identifiers

RefSeq protein ID
 
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