Sirtuin 4 (Q21988572)

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mammalian protein found in Mus musculus

NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Regulatory protein SIR2 homolog 4
Sirt4
NAD-dependent protein biotinylase sirtuin-4
3.5.1.-
SIR2-like protein 4
NAD-dependent ADP-ribosyltransferase sirtuin-4
NAD-dependent protein deacetylase sirtuin-4
2.4.2.-

Language	Label	Description	Also known as
English	Sirtuin 4	mammalian protein found in Mus musculus	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Regulatory protein SIR2 homolog 4 Sirt4 NAD-dependent protein biotinylase sirtuin-4 3.5.1.- SIR2-like protein 4 NAD-dependent ADP-ribosyltransferase sirtuin-4 NAD-dependent protein deacetylase sirtuin-4 2.4.2.-

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Sirtuin, class II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8R216

DHS-like NAD/FAD-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8R216

Sirtuin, catalytic core small domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8R216

Sirtuin family, catalytic core domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

metal ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

protein binding

determination method or standard

lipoamidase activity

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

hydrolase activity

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

biotinidase activity

determination method or standard

NAD-dependent protein deacetylase activity

determination method or standard

1 reference

24 April 2018

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R216&geneProductId=UniProtKB:Q8R216

determination method or standard

NAD+ ADP-ribosyltransferase activity

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

zinc ion binding

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

mitochondrial matrix

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

determination method or standard

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

mitochondrial inner membrane

determination method or standard

1 reference

14 February 2019

Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

biological process

peptidyl-lysine deacetylation

determination method or standard

1 reference

14 February 2019

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

negative regulation of insulin secretion

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

positive regulation of lipid biosynthetic process

determination method or standard

1 reference

14 February 2019

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

regulation of glutamine family amino acid metabolic process

determination method or standard

1 reference

14 February 2019

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

negative regulation of fatty acid oxidation

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

regulation of pyruvate dehydrogenase activity

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

cellular response to DNA damage stimulus

determination method or standard

glutamine metabolic process

determination method or standard

tricarboxylic acid metabolic process

determination method or standard

cellular response to hypoxia

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

protein ADP-ribosylation

determination method or standard

1 reference

24 April 2018

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8R216&geneProductId=UniProtKB:Q8R216

determination method or standard

protein deacetylation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8R216

determination method or standard

Sirtuin family, catalytic core domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8R216

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000107697

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000107697

ENSMUSP00000107698

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000107698

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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