RAR-related orphan receptor gamma (Q21991407)

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mammalian protein found in Mus musculus

Rorc
nuclear receptor subfamily 1 group F member 3
TOR
RAR-related orphan receptor C
retinoid-related orphan receptor-gamma
nuclear receptor ROR-gamma
thymus orphan receptor
nuclear receptor RZR-gamma

Language	Label	Description	Also known as
English	RAR-related orphan receptor gamma	mammalian protein found in Mus musculus	Rorc nuclear receptor subfamily 1 group F member 3 TOR RAR-related orphan receptor C retinoid-related orphan receptor-gamma nuclear receptor ROR-gamma thymus orphan receptor nuclear receptor RZR-gamma

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Nuclear hormone receptor-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51450

Zinc finger, NHR/GATA-type

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51450

nuclear receptor ROR

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51450

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

determination method

3 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

24 April 2018

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

DNA-binding transcription factor activity

determination method

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

zinc ion binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

metal ion binding

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

steroid hormone receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

nuclear receptor activity

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

protein binding

determination method

3 references

14 February 2019

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

transcription coactivator binding

determination method

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

oxysterol binding

determination method

1 reference

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

ligand-activated transcription factor activity

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

determination method

2 references

sequence-specific DNA binding

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

determination method

6 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

external side of plasma membrane

determination method

1 reference

14 February 2019

The transcription factor Th-POK negatively regulates Th17 differentiation in Vα14i NKT cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

biological process

cell differentiation

determination method

1 reference

14 February 2019

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

interleukin-17 production

determination method

1 reference

14 February 2019

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

T cell differentiation in thymus

determination method

1 reference

14 February 2019

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

regulation of gamma-delta T cell differentiation

determination method

1 reference

14 February 2019

Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

rhythmic process

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

negative regulation of thymocyte apoptotic process

determination method

1 reference

24 April 2018

RORgammat recruits steroid receptor coactivators to ensure thymocyte survival

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

circadian regulation of gene expression

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

regulation of fat cell differentiation

determination method

1 reference

14 February 2019

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

multicellular organism development

determination method

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

regulation of steroid metabolic process

determination method

1 reference

14 February 2019

Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

positive regulation of transcription, DNA-templated

determination method

protein phosphorylation

determination method

1 reference

14 February 2019

IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

mucosa-associated lymphoid tissue development

determination method

1 reference

14 February 2019

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

intracellular receptor signaling pathway

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

regulation of glucose metabolic process

determination method

1 reference

14 February 2019

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

alpha-beta T cell differentiation

determination method

1 reference

14 February 2019

Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

xenobiotic metabolic process

determination method

1 reference

14 February 2019

Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

positive regulation of circadian rhythm

determination method

1 reference

14 February 2019

RORγ directly regulates the circadian expression of clock genes and downstream targets in vivo

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

adipose tissue development

determination method

1 reference

14 February 2019

Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

T-helper 17 cell differentiation

determination method

3 references

24 April 2018

The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

24 April 2018

T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

24 April 2018

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

Peyer's patch development

determination method

1 reference

24 April 2018

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

T-helper cell differentiation

determination method

1 reference

24 April 2018

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P51450&geneProductId=UniProtKB:P51450

determination method

lymph node development

determination method

1 reference

14 February 2019

An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

steroid hormone mediated signaling pathway

determination method

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

regulation of transcription, DNA-templated

determination method

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

negative regulation of transcription by RNA polymerase II

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

cellular response to sterol

determination method

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

T-helper 17 cell differentiation

determination method

1 reference

14 February 2019

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P51450

determination method

Nuclear hormone receptor, ligand-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51450

nuclear hormone receptor-type zinc finger

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P51450

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000143610

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143610

ENSMUSP00000029795

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000029795

ENSMUSP00000143763

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000143763

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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