Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology (Q28507698)

24 January 2017

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14 January 2020

title

Enforced expression of GATA3 allows differentiation of IL-17-producing cells, but constrains Th17-mediated pathology (English)

2 references

24 January 2017

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14 January 2020

0 references

1 reference

Interleukin 17A

1 reference

GATA binding protein 3

1 reference

Interleukin 13

1 reference

RAR-related orphan receptor gamma

1 reference

Interleukin 4

1 reference

Interleukin 2 receptor, alpha chain

1 reference

CD69 antigen

1 reference

Claudia Ribeiro de Almeida

author

3

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author name string

Jan Piet van Hamburg

1

2 references

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Marloes van Zwam

4

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Marjan van Meurs

5

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14 January 2020

Edwin de Haas

6

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14 January 2020

Louis Boon

7

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14 January 2020

Marjolein J W de Bruijn

2

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Janneke N Samsom

8

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Rudi W Hendriks

9

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14 January 2020

language of work or name

English

0 references

publication date

1 September 2008

2 references

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European Journal of Immunology

14 January 2020

published in

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volume

38

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issue

9

2 references

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page(s)

2573-2586

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The lineage decisions of helper T cells

14 January 2020

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GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiation

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

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Transforming growth factor-beta induces development of the T(H)17 lineage

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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells

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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

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IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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Cutting edge: TGF-beta inhibits Th type 2 development through inhibition of GATA-3 expression.

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A novel transcription factor, T-bet, directs Th1 lineage commitment

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Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo.

21 January 2018

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Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice.

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7 January 2021

Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation

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7 January 2021

Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level

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7 January 2021

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

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7 January 2021

GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet

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7 January 2021

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

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7 January 2021

CD8 T Cell-Specific Downregulation of Histone Hyperacetylation and Gene Activation of the IL-4 Gene Locus by ROG, Repressor of GATA

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7 January 2021

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4

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7 January 2021

Targeting of the transcription factor STAT4 by antisense phosphorothioate oligonucleotides suppresses collagen-induced arthritis

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7 January 2021

Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells

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7 January 2021

IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

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7 January 2021

Could TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes, or rheumatoid arthritis: a register study

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7 January 2021

Identifiers

DOI

10.1002/EJI.200737840

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18792410%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

2 references

24 January 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18792410%20AND%20SRC:MED&resulttype=core&format=json