SH2 domain-containing protein 1B (Q21991445)

http://www.ebi.ac.uk/interpro/protein/O35324

EAT-2, SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

21 March 2016

1 reference

21 March 2016

phosphotyrosine residue binding

English

molecular function

1 reference

14 February 2019

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

3 references

14 February 2019

Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

14 February 2019

Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

signaling adaptor activity

IPI

1 reference

14 February 2019

Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

intracellular anatomical structure

NAS

cell component

1 reference

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O35324&geneProductId=UniProtKB:O35324

negative regulation of natural killer cell mediated cytotoxicity

ISO

biological process

1 reference

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

positive regulation of signal transduction

IDA

1 reference

14 February 2019

Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

negative regulation of interferon-gamma production

NAS

1 reference

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

negative regulation of peptidyl-tyrosine phosphorylation

1 reference

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

innate immune response

1 reference

14 February 2019

leukocyte activation involved in immune response

IEA

1 reference

14 February 2019

Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

IDA

adaptive immune response

1 reference

14 February 2019

positive regulation of natural killer cell mediated cytotoxicity

IEA

natural killer cell inhibitory signaling pathway

IGI

1 reference

14 February 2019

Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

positive regulation of natural killer cell mediated immunity

1 reference

14 February 2019

Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

positive regulation of innate immune response

1 reference

14 February 2019

Expression of the SLAM family of receptors adapter EAT-2 as a novel strategy for enhancing beneficial immune responses to vaccine antigens

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

IDA

immune system process

1 reference

14 February 2019

positive regulation of peptidyl-tyrosine phosphorylation

IEA

1 reference

14 February 2019

Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O35324

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35324

EAT-2, SH2 domain

1 reference

stated in

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O35324

Identifiers

1 reference

21 March 2016

1 reference

21 March 2016